?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F9616%2F&rft.title=Synthetic+Studies+toward+Biologically+Active+Quinones+and+Alkaloids&rft.creator=Joo%2C+Beomjun&rft.description=Part+1+describes+the+synthesis+and+biological+evaluation+of+small-molecule+phosphatase+inhibitors.+The+targets+for+the+synthesized+compounds+are+mainly+Cdc25+phosphatases%2C+which+play+a+key+role+in+regulating+cell+cycle+and+are+often+over-expressed+in+cancers.+Highlights+of+the+synthesis+are+the+amide+bond+formation%2C+the+synthesis+of+secondary+amines+via+o-Ns+chemistry%2C+the+ring+opening+of+the+lactam+by+the+amine%2C+the+preparation+of+various+(iso)quinolinediones+and+the+substitution+reactions+of+(iso)quinolinediones+with+amines+and+thiols.+The+synthesis+and+reaction+of+isoquinonlinediones+are+particularly+highlighted+in+the+total+synthesis+of+caulibugulones+A-E.+Biological+assays+established+the+(iso)quinolinediones+as+new+phosphatase+inhibitors+with+considerable+selectivity+against+the+Cdc25+family+of+DSPases.Part+2+describes+the+synthetic+studies+toward+the+total+synthesis+of+parvistemonine%2C+which+represents+one+of+the+most+challenging+synthetic+targets+among+Stemona+alkaloids.+The+studies+are+mainly+focused+on+the+development+of+a+fragmentation+strategy+aimed+at+the+total+synthesis+of+parvistemonine.+Highlights+of+these+studies+are+the+synthesis+of+vinyl+azides%2C+the+fragmentation+reaction+of+tertiary+alcohols+and+the+use+of+the+trimethylsilyl-methylene+group+as+a+directing+group+in+the+fragmentation+reaction.+These+studies+demonstrate+a+novel+vinylogous+azido+alcohol+fragmentation+reaction+in+simple+model+systems+and+a+regioselective+fragmentation+reaction+of+hydroxy+indolines.&rft.date=2005-01-31&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F9616%2F1%2Fjoodissertation.pdf&rft.identifier=++Joo%2C+Beomjun++(2005)+Synthetic+Studies+toward+Biologically+Active+Quinones+and+Alkaloids.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++