eprintid: 9111
rev_number: 5
userid: 6
dir: disk0/00/00/91/11
datestamp: 2011-11-10 19:59:39
lastmod: 2016-11-15 13:49:09
status_changed: 2011-11-10 19:59:39
type: thesis_degree
metadata_visibility: show
contact_email: n_f_ware@yahoo.com
item_issues_count: 0
eprint_status: archive
creators_name: Ware, Nathaniel F.
creators_email: n_f_ware@yahoo.com
title: Synthesis of Potential SH2 Domain Ligands Containing Phosphate Group Mimics
ispublished: unpub
divisions: sch_as_chemistry
full_text_status: public
keywords: medicinal chemistry; peptide coupling; peptidomimetic; STAT3 target
abstract: This thesis describes the synthesis of two peptidomimetics containing heterocyclicphosphate group mimics. These compounds are based on a potent STAT3 inhibitor andtherefore have the potential of being SH2 domain ligands. Due to problems with the purificationof the final products, the mimetic containing the isothiazolidinone (IZD) moiety was obtained in< 87% purity and the 5,6-dihydro-2H-1,2,6-thiadiazine 1,1-dioxide (TDA) analog was isolated in< 57% purity based on NMR analysis.
date: 2011-09-14
date_type: completed
institution: University of Pittsburgh
refereed: TRUE
etdcommittee_type: committee_chair
etdcommittee_type: committee_member
etdcommittee_type: committee_member
etdcommittee_name: Wipf, Peter
etdcommittee_name: Curran, Dennis P.
etdcommittee_name: Koide, Kazunori
etdcommittee_email: pwipf@pitt.edu
etdcommittee_email: curran@pitt.edu
etdcommittee_email: koide@pitt.edu
etdcommittee_id: PWIPF
etdcommittee_id: CURRAN
etdcommittee_id: KOIDE
etd_defense_date: 2011-08-19
etd_approval_date: 2011-09-14
etd_submission_date: 2011-08-15
etd_access_restriction: 5_year
etd_patent_pending: FALSE
assigned_doi: doi:10.5195/pitt.etd.2011.9111
thesis_type: thesis
degree: MS
committee: Peter Wipf (pwipf@pitt.edu) - Committee Chair
committee: Dennis P. Curran (curran@pitt.edu) - Committee Member
committee: Kazunori Koide (koide@pitt.edu) - Committee Member
etdurn: etd-08152011-110256
other_id: http://etd.library.pitt.edu/ETD/available/etd-08152011-110256/
other_id: etd-08152011-110256
citation:   Ware, Nathaniel F.  (2011) Synthesis of Potential SH2 Domain Ligands Containing Phosphate Group Mimics.  Master's Thesis, University of Pittsburgh.    (Unpublished)  
document_url: http://d-scholarship-dev.library.pitt.edu/9111/1/warenf_etd2011_v3.pdf