?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F8929%2F&rft.title=Synthesis+and+NMR+Strcuture+Determination+of+Bis-Amino-Acid+Oligomers&rft.creator=Morgan%2C+Paul+M&rft.description=in+chapters+2+and+3%2C+I+present+the+synthesis+of+three+bis-amino+acid+monomers.+The+pro3+class+of+monomers+were+designed+to+create+a+sharp+turn+in+a+bis-amino+acid+oligomeric+sequences.+The+pro3(2S4S)+monomer+was+synthesised%2C+but+had+an+unexpected+tendency+to+epimerize+when+incorporated+into+an+oligomer.+The+syntheses+of+two+pip5+class+monomers+were+completed+in+13%25+overall+yield+and+21%25+overall+yield.In+the+fourth+chapter%2C+I+present+the+first+use+of+residual+dipolar+coupling+(RDC)measurement+in+the+solution+structure+determination+of+a+bis-amino-aicd+oligomer.+This+technique+allows+the+determination+of+bond+orientations+within+a+molecule+with+respect+to+the+magnetic+field+of+a+nuclear+magnetic+resonance+(NMR)spectrometer.+I+determined+that+the+information+gained+from+the+measurement+of+RDCs+can+be+used+to+filter+a+library+of+conformational+models+to+select+the+best+fit+model+to+the+RDC+data.+The+best+fit+model+was+found+to+ve+the+lowest+energy+conformation+of+the+bis-amino+acid+oligomer.&rft.date=2008-01-28&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F8929%2F1%2Fpmorgan_122007a.pdf&rft.identifier=++Morgan%2C+Paul+M++(2008)+Synthesis+and+NMR+Strcuture+Determination+of+Bis-Amino-Acid+Oligomers.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++