?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F8216%2F&rft.title=Diffusion+and+Solid+State+NMR+Studies+of+Structures+in+Model+Biological+Membranes&rft.creator=CHO%2C++HYO+SOON&rft.description=We+studied+the+structures+in+model+biological+membranes+using+solid+state+NMR+and+NMR+diffusion+microscopy.+We+have+created+a+stable+bicelle+system+containing+cholesterol%2C+unsaturated+and+saturated+lipids%2C+capable+of+forming+micron-scale+lipid+domains+and+suitable+for+structural+biology+studies+of+membrane+proteins.+The+domains+were+observed+by+measuring+time-dependent+diffusion+constants+reflecting+restricted+diffusion+of+the+lipids+within+micron-scale+regions+of+the+bicelles.+We+observed+the+correlation+of+bilayer+structure+of+diverse+bicelle+systems+with+their+alignment+capability%2C+using+31P+NMR+to+measure+the+density+of+perforations+in+the+bilayer+as+a+function+of+bicelle+alignment.+We+found+a+critical+density+for+optimal+bicelle+alignment%2C+applicable+to+bicelles+of+different+lipid+compositions.+We+were+able+to+measure+the+effect+of+the+perforation+density+on+micron-scale+domain+formation+in+lipid+bilayers.+The+perforations+redistributed+line+active+lipids+within+the+bilayer%2C+affecting+the+bulk+line+tension+of+the+lipid+domain.+This+work+demonstrated+that+membrane+topology+can+control+domain+formation.&rft.date=2011-09-16&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F8216%2F1%2F06232011Cho.pdf&rft.identifier=++CHO%2C+HYO+SOON++(2011)+Diffusion+and+Solid+State+NMR+Studies+of+Structures+in+Model+Biological+Membranes.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++