?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F8076%2F&rft.title=The+Association+of+Human+Herpesvirus+8+and+a+Single+Nucleotide+Polymorphism+in+the+gp130+Signaling+Receptor+in+Prostate+Cancer&rft.creator=Montgomery%2C+Jill+Deann&rft.description=We+have+previously+demonstrated+a+significant+association+between+human+herpesvirus+8+(HHV-8)+seroprevalence+among+men+with+prostate+cancer+in+the+Caribbean+island+of+Tobago+compared+to+cancer+free+men.+HHV-8+DNA+has+been+detected+in+semen+and+prostatic+tissues+in+some%2C+but+not+all+reports.+I+have+performed+immunohistochemistry+(IHC)+on+prostate+tissues+from+HHV-8+seropositive+men+from+the+United+States+and+Tobago+with+prostate+cancer+for+the+expression+of+viral+proteins+and+determined+if+expression+of+these+proteins+are+associated+with+increased+inflammation.+My+results+demonstrate+the+presence+of+viral+proteins+in+prostates+from+seropositive+men+and+among+tissues+expressing+these+viral+proteins%2C+there+is+increased+inflammation+as+measured+by+macrophage+infiltrate.+I+have+also+looked+for+the+presence+of+polymorphisms+in+several+genes+previously+associated+with+increased+risk+of+prostate+cancer+to+determine+if+there+was+a+genetic+link+with+the+greater+risk+for+prostate+cancer+in+Tobago.+We+have+found+single+nucleotide+polymorphism+in+the+IL-6+gp130+signaling+receptor+that+is+associated+with+increased+prostate+cancer+risk+among+HHV-8+seropositive+men.+The+public+health+relevance+observed+by+these+results+suggests+an+interaction+between+HHV-8+infection%2C+increased+inflammation+and+genetic+polymorphisms+resulting+in+increased+prostate+cancer+risk.+I+hypothesize+that+HHV-8+is+a+cofactor+for+prostate+cancer+in+Tobago+by+establishing+a+chronic+infection+which+leads+to+chronic+inflammation+and+ultimately+prostate+cancer.&rft.date=2008-09-28&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F8076%2F1%2FJill_Montgomery_062008_ETD_Final.pdf&rft.identifier=++Montgomery%2C+Jill+Deann++(2008)+The+Association+of+Human+Herpesvirus+8+and+a+Single+Nucleotide+Polymorphism+in+the+gp130+Signaling+Receptor+in+Prostate+Cancer.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++