eprintid: 7932
rev_number: 5
userid: 6
dir: disk0/00/00/79/32
datestamp: 2011-11-10 19:45:35
lastmod: 2016-11-15 13:43:53
status_changed: 2011-11-10 19:45:35
type: thesis_degree
metadata_visibility: show
contact_email: jiz5@pitt.edu
item_issues_count: 0
eprint_status: archive
creators_name: Zhang, Jian
creators_email: jiz5@pitt.edu
creators_id: JIZ5
title: SYNTHESIS AND NEAR INFRARED LUMINESCENT PROPERTIES OF LANTHANIDE COMPLEXES
ispublished: unpub
divisions: sch_as_chemistry
full_text_status: public
keywords: lanthanide; luminescence; near infrared
abstract: In vivo near-infrared (NIR) fluorescence microscopy and imagery is an emerging research area in biology. Organic dyes currently tested for NIR imagery have very severe limitations such as rapid photobleaching. This drastically limits the sample exposure time and/or prevents the experiment to be repeated. Lanthanide complexes have NIR luminescence properties which have strong resistance to photo-bleaching, long luminescence lifetimes and sharp emission bands. In addition, the emission band energies are independent from the experimental condition. All these properties make them the most promising agents for NIR imagery. In this thesis, it was demonstrated that tropolonate ligands can be used as an efficient sensitizer for several luminescent lanthanide cations (Nd, Ho, Er, Tm, Yb) emitting in the NIR. One octadentate ligand was developed to fulfill the complete coordination requirements of lanthanide cations in order to achieve increased stability of the complex to sustain physiological conditions to maximize the protection of the coordinated lanthanide cation against non-radiative deactivation. To study and rationalize the mechanism of ligand to lanthanide of energy transfer, derivatives of tropolone and their corresponding complexes are synthesized. The mechanism of the energy transfer can be used to design lanthanide complexes with controlled properties.
date: 2006-09-29
date_type: completed
institution: University of Pittsburgh
refereed: TRUE
etdcommittee_type: committee_chair
etdcommittee_type: committee_member
etdcommittee_type: committee_member
etdcommittee_name: Petoud, Stephane
etdcommittee_name: Waldeck, David
etdcommittee_name: Meyer, Tara
etdcommittee_email: spetoud@pitt.edu
etdcommittee_email: dave@pitt.edu
etdcommittee_email: tmeyer@pitt.edu
etdcommittee_id: SPETOUD
etdcommittee_id: DAVE
etdcommittee_id: TMEYER
etd_defense_date: 2004-11-09
etd_approval_date: 2006-09-29
etd_submission_date: 2006-05-22
etd_access_restriction: immediate
etd_patent_pending: FALSE
assigned_doi: doi:10.5195/pitt.etd.2011.7932
thesis_type: thesis
degree: MS
committee: Stephane Petoud (spetoud@pitt.edu) - Committee Chair
committee: David Waldeck (dave@pitt.edu) - Committee Member
committee: Tara Meyer (tmeyer@pitt.edu) - Committee Member
etdurn: etd-05222006-225623
other_id: http://etd.library.pitt.edu/ETD/available/etd-05222006-225623/
other_id: etd-05222006-225623
citation:   Zhang, Jian  (2006) SYNTHESIS AND NEAR INFRARED LUMINESCENT PROPERTIES OF LANTHANIDE COMPLEXES.  Master's Thesis, University of Pittsburgh.    (Unpublished)  
document_url: http://d-scholarship-dev.library.pitt.edu/7932/1/Jianzhangthesis2006.pdf