?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F7687%2F&rft.title=Applications+of+bis-amino+acid+oligomers&rft.creator=Bird%2C+Gregory+H.&rft.description=The+ability+to+precisely+position+functionality+in+three-dimensional+space+is+a+long+term+goal+for+our+group.+Some+progress+has+been+made+so+far.+Using+oligomers+of+our+bis-amino+acids%2C+we+are+able+to+control+the+distance+between+two+groups%2C+ranging+from+2-4nm.+Also+we+are+able+to+control+shape+and+curvature+by+incorporating+monomers+that+make+bends+or+kinks.+There+are+many+potential+applications.+Some+of+the+most+powerful+are+described+in+the+following+pages.+We+have+made+a+bivalent+ligand+for+Cholera+Toxin+varying+the+number+of+monomers+and+found+that+all+bivalent+molecules+that+bind+more+tightly+than+the+natural+ligand+GM1.+The+oligomeric+scaffold+is+rigid+and+the+linker+contains+about+5+rotatable+bonds.+We+have+made+bivalent+vancomycins+and+bivalent+D-Ala-D-Ala%2C+each+consisting+of+linkers+of+between+1-6+building+blocks.+These+molecules+should+be+capable+of+associating+into+matched+or+mismatched+bivalent+pairs.+In+addition%2C+we+have+made+large+macrocycles+capable+of+forming+a+binding+pocket.+Ligands+for+these+receptors+will+be+identified+using+phage+display.+Also%2C+our+rigid+chiral+scaffolds+have+been+studied+to+determine+the+influence+of+chirality+on+the+efficiency+of+electron+transfer.+Finally%2C+a+scaffold+detergent+was+synthesized%2C+with+the+application+of+solubilization+of+membrane+proteins+in+mind.+These+are+all+promising+applications+of+our+unique+technology+and+will+be+explored+further+in+the+future.&rft.date=2009-02-10&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F7687%2F1%2FBird_GregoryH_May17_2006.pdf&rft.identifier=++Bird%2C+Gregory+H.++(2009)+Applications+of+bis-amino+acid+oligomers.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++