@unpublished{pittir7486,
           month = {June},
           title = {Development of E-and Z-Selective Base-Catalyzed Redox Isomerizations and Ene-Diene Cross Metathesis},
          author = {John P. Sonye},
            year = {2006},
        keywords = {cross metathesis; diene; redox isomerization; zebrafish},
             url = {http://d-scholarship-dev.library.pitt.edu/7486/},
        abstract = {{\ensuremath{\gamma}}-Oxo-{\ensuremath{\alpha}},{\ensuremath{\beta}}-alkenoates are found in several natural products and are versatile syntheticintermediates. We have developed methods to selectively prepare E and Z-alkenoates from {\ensuremath{\gamma}}-hydroxy-{\ensuremath{\alpha}},{\ensuremath{\beta}}-alkynoates wherein the optimization, mechanism, and scope of the reactions are described. Biological testing of {\ensuremath{\gamma}}-oxo-{\ensuremath{\alpha}},{\ensuremath{\beta}}-alkenoates and their derivatives in zebrafish embryos also are discussed.Since the development of ruthenium alkylidene catalysts, olefin metathesis has become auseful method in synthetic organic chemistry. However, certain areas of metathesis haveremained under-researched; in particular, the cross metathesis of a 1,3-diene with a terminalolefin known as ene-diene cross metathesis (EDCM). The attempt at optimization of EDCMreactions using a general model is also discussed.}
}