eprintid: 7285
rev_number: 4
userid: 6
dir: disk0/00/00/72/85
datestamp: 2011-11-10 19:38:28
lastmod: 2016-11-15 13:40:51
status_changed: 2011-11-10 19:38:28
type: thesis_degree
metadata_visibility: show
contact_email: tkellar@adelphia.net
item_issues_count: 0
eprint_status: archive
creators_name: Kellar, Terry Allen
creators_email: tkellar@adelphia.net
title: The Pederin Family: A Synthetic Overview
ispublished: unpub
divisions: sch_as_chemistry
full_text_status: public
keywords: antitumor; antiviral; cancer; diastereomeric; enantiomeric; immunosuppressant; total synthesis
abstract: A comprehensive synthetic review of the pederin family of cytotoxins, including pederin, the mycalamides, and psymberin, is presented. A number of approaches to the synthesis of these molecules is covered, including pederic acid, the tetrahydropyranyl ring of pederin, the trioxadecalin ring of the mycalamides, and psymberin fragments. Coupling strategies for these compounds are also summarized. An overview of biological activity at various positions of mycalamide A, as well as some analogs, is given.
date: 2006-06-29
date_type: completed
institution: University of Pittsburgh
refereed: TRUE
etdcommittee_type: committee_chair
etdcommittee_type: committee_member
etdcommittee_type: committee_member
etdcommittee_name: Floreancig, Paul
etdcommittee_name: Brummond, Kay
etdcommittee_name: Koide, Kazunori
etdcommittee_email: florean@pitt.edu
etdcommittee_email: kbrummon@pitt.edu
etdcommittee_email: koide@pitt.edu
etdcommittee_id: FLOREAN
etdcommittee_id: KBRUMMON
etdcommittee_id: KOIDE
etd_defense_date: 2006-04-06
etd_approval_date: 2006-06-29
etd_submission_date: 2006-04-18
etd_access_restriction: immediate
etd_patent_pending: FALSE
assigned_doi: doi:10.5195/pitt.etd.2011.7285
thesis_type: thesis
degree: MS
committee: Paul Floreancig (florean@pitt.edu) - Committee Chair
committee: Kay Brummond (kbrummon@pitt.edu) - Committee Member
committee: Kazunori Koide (koide@pitt.edu) - Committee Member
etdurn: etd-04182006-204913
other_id: http://etd.library.pitt.edu/ETD/available/etd-04182006-204913/
other_id: etd-04182006-204913
citation:   Kellar, Terry Allen  (2006) The Pederin Family: A Synthetic Overview.  Master's Thesis, University of Pittsburgh.    (Unpublished)  
document_url: http://d-scholarship-dev.library.pitt.edu/7285/1/kellar2006etd.pdf