eprintid: 7053 rev_number: 4 userid: 6 dir: disk0/00/00/70/53 datestamp: 2011-11-10 19:36:12 lastmod: 2016-11-15 13:39:47 status_changed: 2011-11-10 19:36:12 type: thesis_degree metadata_visibility: show contact_email: akmethod@mac.com item_issues_count: 0 eprint_status: archive creators_name: Keller, Adam I. creators_email: akmethod@mac.com title: Homolytic Aromatic Substitution, Conformational Dynamics of Dihydrophenanthridines, and High-Throughput Synthesis of Amides with Fluorous Technology: Methodologies in Reaction, Analysis, and Separation ispublished: unpub divisions: sch_as_chemistry full_text_status: public keywords: 2DEXSY; AM1; amide rotamer; aryl bromide; aryl halide; aryl iodide; aryl radical; biphenyl; cartridge; chem3D; control reaction; Curran; D2DNMR; DIC; energy barrier; energy minimization; EXSY; fluorous carbodiimide; fluorous technologies; fluorous urea; FTI; GC; GC-MS; incorporated; internal standard; mixing time; molecular modeling; N-acylurea; nOe; oxygen; phenanthridine; pulse sequence; radical mechanism; rotational barrier; silica gel; silicon NMR; SPE; tributyltin hydride; TTMSS; twisted amide; vinyl radical; VTNMR abstract: Homolytic aromatic substitution encompasses a wide range of synthetic transformations based on inter- and intramolecular additions of radicals to arenes. Additions of radicals derived from aryl iodides to arenes are promoted by tris(trimethylsilyl)silane and occur under exceptionally mild conditions in non-degassed benzene. Experimental observations led to a proposed mechanism involving reaction of the intermediate cyclohexadienyl radical with dioxygen to generate the aromatic product and the hydroperoxy radical. This methodology was extended to the synthesis of biaryl and heterocyclic compounds.N-Acetyldihydrophenanthridines exhibit remarkable conformational dynamics that are observable on the NMR timescale. Semiempirical calculations were performed to understand their conformational preferences. The predictions derived from the calculated structures were verified by x-ray crystallography, two-dimensional exchange and variable temperature NMR spectroscopy. The rate constants for conformational switching were calculated by a matrix-based routine with data extracted from the two-dimensional exchange spectra.A fluorous equivalent of diisopropylcarbodiimide (FDIC) was synthesized to overcome the separation problems encountered when conducting solution-phase, carbodiimide mediated acyl couplings. The reactivity of the fluorous analog was not greatly affected by the presence of a fluorous domain, and was equally as effective as diisopropylcarbodiimide in facilitating amide bond formation. Coupled with a reverse F-SPE strategy, FDIC mediated couplings were conducted to provide the target amides in high-purities (95-99%). A small library of amides was prepared in a high-throughput fashion to demonstrate the utility of this approach. date: 2007-06-21 date_type: completed institution: University of Pittsburgh refereed: TRUE etdcommittee_type: committee_chair etdcommittee_type: committee_member etdcommittee_type: committee_member etdcommittee_type: committee_member etdcommittee_name: Curran, Dennis P etdcommittee_name: Day, Billy etdcommittee_name: Wilcox, Craig etdcommittee_name: Floreancig, Paul etdcommittee_email: curran@pitt.edu etdcommittee_email: bday@pitt.edu etdcommittee_email: daylite@pitt.edu etdcommittee_email: florean@pitt.edu etdcommittee_id: CURRAN etdcommittee_id: BDAY etdcommittee_id: DAYLITE etdcommittee_id: FLOREAN etd_defense_date: 2007-03-02 etd_approval_date: 2007-06-21 etd_submission_date: 2007-04-12 etd_access_restriction: immediate etd_patent_pending: FALSE assigned_doi: doi:10.5195/pitt.etd.2011.7053 thesis_type: dissertation degree: PhD committee: Dennis P. Curran (curran@pitt.edu) - Committee Chair committee: Billy Day (bday@pitt.edu) - Committee Member committee: Craig Wilcox (daylite@pitt.edu) - Committee Member committee: Paul Floreancig (florean@pitt.edu) - Committee Member etdurn: etd-04122007-142347 other_id: http://etd.library.pitt.edu/ETD/available/etd-04122007-142347/ other_id: etd-04122007-142347 citation: Keller, Adam I. (2007) Homolytic Aromatic Substitution, Conformational Dynamics of Dihydrophenanthridines, and High-Throughput Synthesis of Amides with Fluorous Technology: Methodologies in Reaction, Analysis, and Separation. Doctoral Dissertation, University of Pittsburgh. (Unpublished) document_url: http://d-scholarship-dev.library.pitt.edu/7053/1/KellerAI.pdf