?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F6523%2F&rft.title=Experimental+and+Theoretical+Investigations+in+Solid+Phase%3Cbr+%2F%3E+Reaction+Kinetics+and+Noncovalent+Interactions+in+Water&rft.creator=Bhayana%2C+Brijesh&rft.description=Factors+affecting+reaction+rates+in+polystyrene+beads+used+in+solid+phase+organic+synthesis+have+been+studied.+The+role+of+diffusion+and+reagent+partitioning+has+been+examined+theoretically+and+experimentally.+Both+of+these+factors+have+been+found+to+influence+the+reaction+kinetics+of+common+solid+phase+organic+synthesis+reactions.+A+mathematical+model+to+analyze+a+simple+bimolecular+reaction+inside+a+bead+has+been+developed+and+successfully+applied+to+the+experimental+data+to+obtain+quantitative+information+on+the+influence+of+diffusion+and+reagent+partitioning+on+the+reaction+rates.+The+effects+of+diffusion+generally+increase+with+the+size+and+decreased+swelling+of+the+beads.+Under+many+common+reaction+conditions%2C+however%2C+these+effects+may+not+be+very+significant.+General+guidelines+to+identify+these+conditions+have+been+developed.%3Cbr+%2F%3E+A+water-soluble+torsion+balance+to+study+noncovalent+interactions+in+aqueous+media+has+been+synthesized.+The+folding+energies+of+new+balances+were+found+to+be+higher+in+water+than+in+organic+solvents.+This+increase+can+be+partially+attributed+to+hydrophobic+forces.+Aggregation+and+micelle+formation+were+found+to+increase+folding+in+water%2C+indicating+differences+between+microscopic+and+mesoscopic+hydrophobic+effects.+The+experimental+data+have+been+analyzed+in+the+context+of+the+Lum%2C+Chandler+and+Weeks+theory+of+hydrophobicity+and+evidences+in+its+favor+have+been+found.+The+hydrophobic+response+of+a+fluoromethyl+group+was+found+to+be+similar+to+a+methyl+group+in+two+complementary+torsion+balances.%3Cbr+%2F%3E&rft.date=2007-06-20&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F6523%2F1%2FBrijeshETD3.pdf&rft.identifier=++Bhayana%2C+Brijesh++(2007)+Experimental+and+Theoretical+Investigations+in+Solid+Phase%3Cbr+%2F%3E+Reaction+Kinetics+and+Noncovalent+Interactions+in+Water.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++