?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F39035%2F&rft.title=Transfer+of+DC+instruction+to+T+Cells+via+Extracellular+Vesicles&rft.creator=Thothathri%2C+Subramanian&rft.description=An+overwhelming+push+in+HIV+research+has+been+made+towards+developing+a+%E2%80%98functional+cure%E2%80%99%2C+with+the+overarching+goal+being+to+eliminate+or+control+the+virus+without+the+need+for+continued+antiretroviral+drug+therapy.+Successful+immunotherapeutic+strategies+are+now+mainstream+as+anti-cancer+treatments+have+encouraged+exploration+into+the+development+of+novel+immunotherapies+to+treat+HIV.+Importantly+in+public+health%2C+new+insights+into+the+complexities+of+how+the+immune+system+functions+in+both+health+and+disease+continue+to+provide+room+for+developing+novel+and+improved+therapies.+Because+dendritic+cells+(DC)+play+a+central+role+in+the+crosstalk+between+the+innate+and+adaptive+branches+of+the+immune+response%2C+they+have+been+widely+considered+for+their+therapeutic+potential+for+both+HIV+and+cancer.+Yet+in+order+to+capitalize+on+their+strengths+in+this+regard%2C+there+is+still+a+need+to+better+understand+the+basics+of+how+they+function+and+communicate+with+other+immune+cells.+In+this+study%2C+we+explore+the+basic+role+DC-derived+extracellular+vesicles+play+in+the+immune+crosstalk+between+DC+and+T+cells%2C+characterizing+mechanisms+of+their+release%2C+their+transfer+to+T+cells%2C+their+phenotype%2C+and+their+functional+impact+on+cellular+immune+responses+to+viral+antigens.+It+is+our+position+that+information+gained+from+this+work+may+contribute+to+the+development+of+novel+and+improved+therapies+to+treat+chronic+diseases+such+as+HIV-1+infection&rft.date=2020-07-30&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F39035%2F1%2FThothathriS_MSthesis_April2020.pdf&rft.identifier=++Thothathri%2C+Subramanian++(2020)+Transfer+of+DC+instruction+to+T+Cells+via+Extracellular+Vesicles.++Master's+Thesis%2C+University+of+Pittsburgh.++++(Unpublished)++