?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F38986%2F&rft.title=Regulation+of+Neuroinflammatory+Factors+by+Neuroprotective+MicroRNAs+in+HIV-1+Infected+Microglia&rft.creator=Amirova%2C+Samira&rft.description=Despite+successful+antiretroviral+therapy+(ART)%2C+more+than+half+of+individuals+living+with+HIV-1+exhibit+HIV-1+Associated+Neurocognitive+Disorder+(HAND).+Individuals+with+HAND+experience+a+spectrum+of+cognitive%2C+motor%2C+and%2For+mood+dysfunctions.+Currently%2C+there+are+no+treatment+or+prevention+methods+for+HAND.+HIV-1+virus+enters+through+the+blood-brain+barrier+(BBB)+and+establishes+infection+in+CD4%2B+cells+such+as+macrophages+and+microglia+present+in+the+central+nervous+system+(CNS).+Macrophages+and+microglia+are+the+key+targets+for+HIV-1+in+CNS.+Infected+target+cells+release+inflammatory+cytokines+and+viral+proteins+that+are+exposed+to+neurons.+The+combination+of+viral+and+host+factors+triggers+neuronal+damage+that+results+in+neurodegeneration%2C+the+hallmark+of+HAND+pathology.+Identifying+new+therapeutics+is+important+to+reduce+the+negative+effects+of+HAND%2C+which+has+great+public+health+significance.%0D%0ATo+combat+this+problem%2C+we+propose+to+target+neuroinflammatory+factors+that+have+been+identified+to+have+a+role+in+the+development+of+HAND+using+microRNAs+(miRNAs).+These+miRNAs+target+biological+pathways+including+homeostasis+of+cellular+interaction%2C+regulation+of+neurotoxic+and+neuroprotective+factors%2C+cell+proliferation%2C+and+differentiation.+In+this+study%2C+we+explore+the+effects+of+these+candidate+miRNAs+and+their+role+in+regulating+the+production+of+neuroinflammatory+chemokines+and+cytokines.+By+modulating+the+microglia+response+to+HIV-1+infection%2C+I+will+be+able+to+understand+how+normal+functioning+of+microglia+in+the+CNS+is+interfered+by+virus+infection.+Through+this+knowledge%2C+there+will+be+an+increased+likelihood+of+developing+novel+therapeutic+strategies+and+treatment+for+neurocognitive+disorders.&rft.date=2020-07-30&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F38986%2F1%2FAmirova_SG_MPHthesis_April_2020.pdf&rft.identifier=++Amirova%2C+Samira++(2020)+Regulation+of+Neuroinflammatory+Factors+by+Neuroprotective+MicroRNAs+in+HIV-1+Infected+Microglia.++Master's+Thesis%2C+University+of+Pittsburgh.++++(Unpublished)++