?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F38685%2F&rft.title=Shape+Analysis+Based+Strategies+for+Evaluation+of+Adaptations+in+In+Vivo+Right+Ventricular+Geometry+and+Mechanics+as+Effected+by+Pulmonary+Hypertension&rft.creator=Jing%2C+Xu&rft.description=Pulmonary+hypertension+(PH)+is+a+deadly+disease%2C+which+as+it+progresses+over+time+alters+many+aspects+of+the+afflicted+heart%2C+and+particularly+the+right+ventricle+(RV)%2C+such+as+its+size%2C+shape%2C+and+mechanical+material+properties.+However%2C+due+to+the+limitations+of+what+can+be+measured+noninvasively+in+a+standard+clinical+setting+and+the+difficulty+caused+by+the+intrinsic+complexity+of+the+human+RV%2C+there+has+been+little+success+to-date+to+identify+clinically+obtainable+metrics+of+RV+shape%2C+deformation%2C+or+material+properties+that+are+quantitatively+linked+to+the+onset+and+progression+of+PH.+Towards+addressing+this+challenge%2C+this+work+proposes+the+use+of+the+shape+and+shape+change+of+the+RV%2C+which+is+measurable+from+standard+clinical+imaging%2C+along+with+statistical+analysis+and+inverse+material+characterization+strategies+to+identify+new+metrics+of+RV+mechanical+function+that+will+be+uniquely+predictive+of+the+state+of+the+heart+subject+to+PH.++Thus%2C+this+thesis+can+be+broken+into+two+components%3A+the+first+is+statistical+shape+analysis+of+the+RV%2C+and+the+second+is+inverse+characterization+of+heart+wall+mechanical+material+properties+from+RV+shape+change+and+measurable+hemodynamics.++For+the+statistical+shape+analysis+investigation%2C+a+custom+approach+using+harmonic+mapping+and+proper+orthogonal+decomposition+is+applied+to+determine+the+fundamental+components+of+shape+(i.e.%2C+modes)+from+a+dataset+of+50+patients+with+varying+states+of+PH%2C+including+some+without+PH+at+all.++For+the+inverse+characterization+work%2C+a+novel+method+was+developed+to+estimate+the+heterogeneous+properties+of+a+structure%2C+given+only+the+target+shape+of+that+structure%2C+after+a+known+excitation+is+applied+to+deform+the+structure.+Lastly%2C+the+inverse+characterization+algorithm+was+extended+to+be+applicable+to+actual+in+vivo+cardiac+data%2C+particularly+through+the+inclusion+of+a+registration+step+to+account+for+the+organ-scale+rotation+and+translation+of+the+heart.%0D%0AFuture+work+remains+to+expand+on+the+computational+efficiency+of+this+inverse+solution+estimation+procedure%2C+and+to+further+evaluate+and+improve+upon+the+consistency+and+clinical+interpretability+of+the+material+property+estimates.&rft.date=2020-07-31&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F38685%2F1%2Fjingxu_etdPitt2020.pdf&rft.identifier=++Jing%2C+Xu++(2020)+Shape+Analysis+Based+Strategies+for+Evaluation+of+Adaptations+in+In+Vivo+Right+Ventricular+Geometry+and+Mechanics+as+Effected+by+Pulmonary+Hypertension.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++