?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F38629%2F&rft.title=Progress+Towards+the+Total+Synthesis+of+Petrosaspongiolide+L+and+Small+Molecule+Control+of+Nucleic+Acid+Function&rft.creator=Kilgore%2C+Austin&rft.description=Since+their+discovery+in+1997%2C+the+Petrosaspongiolide+family+of+marine+natural+products+has+gained+interest+due+to+their+potency+and+selectivity+as+phospholipase+A2+inhibitors.+Petrosaspongiolide+L+is+unique+within+this+family+of+compounds+due+to+its+pyridine+containing+tetracyclic+ring+structure+that+closely+resembles+the+biologically+active+Spongidines.+This+pyridine+moiety+makes+it+an+ideal+candidate+to+highlight+a+microwave-mediated+%5B2%2B2%2B2%5D+cyclotrimerization+reaction.+Two+different+strategies+were+attempted+in+the+synthesis+of+a+key+diyne+intermediate.%0D%0AConditional+control+of+nucleic+acid+function+has+become+an+important+method+of+elucidating+gene+function+as+well+as+a+potential+candidate+in+the+treatment+of+multiple+disorders.+Endogenously%2C+non-coding+RNA+utilizes+the+specificity+of+Watson-Crick+base+pairing+to+regulate+gene+expression.+Expanding+on+these+interactions%2C+researchers+have+succeeded+in+manipulating+these+pathways+by+exposing+cells+and+organisms+to+synthetic+plasmids+and+oligonucleotides.+Modifications+to+synthetic+nucleic+acids+(backbone+modifications%2C+caging+groups%2C+etc.)+have+increased+their+stability+and+specificity+while+also+allowing+spatiotemporal+control+of+their+function.+Surprisingly%2C+small+molecule+induced+bioorthogonal+transformations+have+yet+to+be+applied+to+the+control+of+modified+nucleic+acids.+The+progress+towards+the+design+and+optimization+of+synthetic+linkers+capable+of+cleaving+a+nucleic+acid+backbone+via+a+simple+alloc+deprotection+is+discussed+herein.&rft.date=2020-06-08&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F38629%2F7%2FKilgore%2520Final%2520ETD.pdf&rft.identifier=++Kilgore%2C+Austin++(2020)+Progress+Towards+the+Total+Synthesis+of+Petrosaspongiolide+L+and+Small+Molecule+Control+of+Nucleic+Acid+Function.++Master's+Thesis%2C+University+of+Pittsburgh.++++(Unpublished)++