?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F38024%2F&rft.title=An+epidemiological+analysis+of+MDRO+acquisition+in+critically+ill+burn+patients+in+western+Pennslyvania&rft.creator=Solomon%2C+Quinn&rft.description=Rationale%3A+The+growing+public+health+concern+of+antibiotic+resistance+is+becoming+more+critical+and+urgent.+Multi-drug+resistant+organisms+(MDROs)+are+becoming+increasingly+prevalent+in+healthcare+settings+and+physicians+are+faced+with+the+reality+that+treatment+options+are+becoming+scarcer.+Burn+patients+are+a+special+case+within+the+hospitalized+population+as+they+are+potentially+exposed+to+pathogens+internally+through+inhalation+injury%2C+effectively+placing+them+at+a+higher+risk+for+infection.+As+the+first+line+of+defense+is+compromised%2C+burn+injuries+must+be+especially+monitored+as+they+are+highly+susceptible+to+subsequent+infection.+There+is+no+set+standard+of+infection+prevention+for+burn+patients+currently.+Identifying+potential+factors+for+acquiring+an+infection+in+a+sample+may+allow+healthcare+workers+to+better+prevent+transmission+among+high-risk%2C+densely+populated+healthcare+settings.+A+thorough+review+and+breakdown+of+a+select+group+impacted+with+burn+injuries+will+help+elucidate+factors+behind+population+at+increased+risk.+%0D%0AMethods%3A+Data+was+collected+from+burn+patients+admitted+to+the+UPMC+Mercy+Burn+ICU+in+2018+that+fit+set+inclusion+criteria.+Variables+of+interest+include+age%2C+gender%2C+total+body+surface+area+(TBSA)+of+burn%2C+length+of+stay+(LOS)%2C+previous+history+of+MDRO%2C+identified+MDRO+during+hospitalization%2C+and+documented+inhalational+injury+presence.+The+four+MDROs+of+interest+are+methicillin-resistant+Staphylococcus+aureus+(MRSA)%2C+extended-spectrum+beta-lactamase-producing+bacteria+(ESBL)%2C+Vancomycin-resistant+enterococci+(VRE)+and+carbapenem-resistant+Enterobacteriaceae+(CRE).%0D%0AResults%3A+Of+the+roughly+three+thousand+burn+patients+evaluated+for+admission%2C+225+were+admitted+and+48+passed+the+exclusion+criteria.+There+was+a+large+disparity+between+gender%2C+nine+females+and+39+males%2C+in+patients+with+critical+burns.+12+of+the+48+patients+had+a+positive+result+for+an+MDRO+during+their+stay+and+the+majority+(7)+had+a+documented+inhalation+injury.+Of+the+four+evaluated+MDROs%2C+MRSA+was+present+in+nearly+every+case+of+a+positive+MDRO+result.+Patients+with+higher+levels+of+burns+were+associated+with+having+a+longer+LOS+duration.+There+is+also+a+statistically+significant+relationship+between+MDRO+acquisition+and+LOS.+%0D%0AConclusions%3A+The+results+of+this+analysis+reinforce+previous+findings+regarding+the+epidemiology+of+burn+patients%2C+but+also+demonstrate+the+need+for+increased+surveillance+in+healthcare+settings+to+prevent+the+onset+and+spread+of+MDROs.+The+large+proportion+of+MDROs+are+attributed+to+MRSA%2C+supporting+previous+conclusions+and+indicating+the+high+transmission+potential+as+well+as+the+need+to+focus+on+preventative+measures.&rft.date=2020-01-29&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F38024%2F1%2FSolomonQ_MPHThesis_Dec2019.pdf&rft.identifier=++Solomon%2C+Quinn++(2020)+An+epidemiological+analysis+of+MDRO+acquisition+in+critically+ill+burn+patients+in+western+Pennslyvania.++Master's+Thesis%2C+University+of+Pittsburgh.++++(Unpublished)++