?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F&rft.title=Development+and+Applications+of+Enhanced+Multiplexing+to+Better+Understand+Aging%2C+Infection%2C+and+Alzheimer's+Disease&rft.creator=King%2C+Christina%2FD.&rft.description=Proteomics+is+the+wide+%E2%80%93+scale+study+of+proteins%2C+in+which+the+proteome+of+an+organism+is+studied.+Proteomics+experiments+obtain+both+qualitative+and+quantitative+information+by+using+a+combination+of+analytical+techniques+including+liquid+chromatography%2C+ion+mobility%2C+and+mass+spectrometry+(MS).+In+quantitative+experiments%2C+relative+protein+amounts+are+determined+to+gain+a+better+understanding+of+biological+problems+related+to+disease-state%2C+kinetic+changes%2C+and+effects+of+pharmaceutical+products.+In+many+cases%2C+multiple+samples+(e.g.+10s+to+100s)+are+analyzed+to+obtain+statistically+%E2%80%93+significant+results%2C+which+requires+ample+time+(on+the+order+of+several+days+to+weeks).+To+reduce+sample+analysis+time+and+potential+experimental+error%2C+multiplexing+strategies+have+been+developed.+Samples+are+labeled+metabolically%2C+enzymatically%2C+or+chemically+during+sample+preparation%2C+pooled+together%2C+and+analyzed+simultaneously+in+the+mass+spectrometer.+%0D%0A+In+this+body+of+work%2C+multiplexing+strategies+have+been+applied+to+study+aging+and+response+to+infection+in+C.+elegans+and+the+involvement+of+the+periphery+in+Alzheimer%E2%80%99s+disease.+In+addition%2C+the+development+of+analyzing+multiplexed+samples+on+Orbitrap+MS+platforms+will+be+presented.+These+developments+and+applications+contribute+to+science+by+providing+insight+to+two+conditions+that+affect+the+aging+population.&rft.date=2019-01-30&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F2%2FAppendix%2520A%2520Table%2520A2.2.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F3%2FAppendix%2520A%2520Table%2520A2.3.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F9%2FAppendix%2520A%2520Table%2520A2.4.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F10%2FAppendix%2520A%2520Table%2520A2.5.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F11%2FAppendix%2520A%2520Table%2520A2.6.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F12%2FAppendix%2520A%2520Table%2520A2.7.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F13%2FAppendix%2520A%2520Table%2520A2.8.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F14%2FAppendix%2520A%2520Table%2520A2.9.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F15%2FAppendix%2520A%2520Table%2520A2.10.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F16%2FAppendix%2520B%2520Table%2520B3.1.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F17%2FAppendix%2520B%2520Table%2520B3.2.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F18%2FAppendix%2520B%2520Table%2520B3.3.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F19%2FAppendix%2520B%2520Table%2520B3.4.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F20%2FAppendix%2520B%2520Table%2520B3.5.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F21%2FAppendix%2520B%2520Table%2520B3.6.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F22%2FAppendix%2520C%2520Table%2520C4.1.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F23%2FAppendix%2520C%2520Table%2520C4.2.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F35574%2F24%2FAppendix%2520C%2520Table%2520C4.3.xlsx&rft.format=application%2Fvnd.ms-excel&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholar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