<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion"^^ . "Tim-3 is highly expressed on a subset of T cells during T cell exhaustion, in settings of chronic viral infection and in tumors. Using LCMV Clone 13, a model for chronic infection, we have found that Tim-3 is neither necessary nor sufficient for the development of T cell exhaustion. Nonetheless, expression of Tim-3 was sufficient to drive resistance to PD-L1 blockade therapy during chronic infection. Strikingly, expression of Tim-3 promoted the development of short-term effector T cells, at the expense of memory precursor development, following acute infection with LCMV-Armstrong. These effects were accompanied by increased Akt/mTOR signaling in T cells with endogenous or ectopically expressed Tim-3. Conversely, Akt/mTOR signaling was reduced in effector T cells from Tim-3 deficient mice. Thus, Tim-3, while essential for optimal effector T cell responses, but may also contribute to T cell exhaustion is restricting the development of long-lived memory T cells. Taken together, our results suggest that Tim-3 is more similar to co-stimulatory receptors that are upregulated following T cell activation, rather than dominant inhibitory proteins such as PD-1. These findings have significant implications for the development of anti-Tim-3 antibodies as immunotherapy agents for the treatment of cancer, infections, and other matters of public health."^^ . "2018-09-17" . . . . . . . . "Lyndsay"^^ . "Avery"^^ . "Lyndsay Avery"^^ . . . . . . "Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion (PDF)"^^ . . . . . "AveryL_ETD_June2018.pdf"^^ . . . "Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion (Other)"^^ . . . . . . "small.jpg"^^ . . . "Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #34548 \n\nTim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion\n\n" . "text/html" . .