<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "STRAIN-ENABLED PHOSPHINATION AND FLUORINATION REACTIONS"^^ . "Chapter one of this thesis discusses the hydrophosphination of carbodiimides with secondary phosphine boranes. These reactions provide access to phosphaguanidine boranes, which have previously not been studied. A cyclic carbodiimide was also prepared, and hydrophosphination of this substrate provided access to structurally unique phosphaguanidines that bear resemblance to cyclophanes. Chapter two delineates the extension of this hydrophosphination method to functionalize strained carbocycles, namely bicyclo[1.1.0]butanes. The scope and stereoselectivity of this transformation was investigated, and further transformations of the cyclobutyl phosphine products were conducted. Studies on the addition of aromatic and heteroaromatic thiols to bicyclo[1.1.0]butanes are also described in this chapter. Chapter three describes a strain-relieving deoxyfluorination of bicyclo[1.1.0]butyl alcohols. The products of these transformations are fluorinated methylenecyclobutanes, which can be oxidatively transformed into cyclobutanones. Bicyclo[1.1.0]butyl amides were also subjected to fluorination with a high degree of diastereoselectivity. Chapter four details the development of bicyclo[1.1.0]butyl amides as potential androgen receptor antagonists for the treatment of castration-resistant prostate cancer. In the course of these medicinal chemistry studies, an acid-mediated isomerization of bicyclo[1.1.0]butanes to cyclobutenes was discovered."^^ . "2018-06-28" . . . . . . . . "John"^^ . "Milligan"^^ . "John Milligan"^^ . . . . . . "STRAIN-ENABLED PHOSPHINATION AND FLUORINATION REACTIONS (PDF)"^^ . . . "Milligan_ETD_2018_3.pdf"^^ . . . "STRAIN-ENABLED PHOSPHINATION AND FLUORINATION REACTIONS (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "STRAIN-ENABLED PHOSPHINATION AND FLUORINATION REACTIONS (Other)"^^ . . . . . . "preview.jpg"^^ . . . "STRAIN-ENABLED PHOSPHINATION AND FLUORINATION REACTIONS (Other)"^^ . . . . . . "medium.jpg"^^ . . . "STRAIN-ENABLED PHOSPHINATION AND FLUORINATION REACTIONS (Other)"^^ . . . . . . "small.jpg"^^ . . . "STRAIN-ENABLED PHOSPHINATION AND FLUORINATION REACTIONS (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #34056 \n\nSTRAIN-ENABLED PHOSPHINATION AND FLUORINATION REACTIONS\n\n" . "text/html" . .