relation: http://d-scholarship-dev.library.pitt.edu/33990/
title: Synthesis of the Conformationally Controlled β–Turn Mimetic Torsion Balance Core Scaffold
creator: Lypson, Alyssa B.
description: The molecular torsion balance concept was applied to a new conformationally controlled scaffold to accurately evaluate pairwise amino acid interactions in an antiparallel β-sheet motif. The scaffold’s core design combines (ortho-tolyl)amide and o,o,o′-trisubstituted biphenyl structural units to provide a geometry better-suited for intramolecular hydrogen bonding.  The aim of this study was to develop synthetic methods for the core scaffold and to conduct a preliminary investigation into the improved sequence alignment on upper and lower aromatic rings to promote hydrogen bond formation at the correct distance and antiparallel orientation.
date: 2018-06-14
type: University of Pittsburgh ETD
type: PeerReviewed
format: application/pdf
language: en
identifier: http://d-scholarship-dev.library.pitt.edu/33990/1/MS_Thesis_Alyssa_B_Lypson.pdf
identifier:   Lypson, Alyssa B.  (2018) Synthesis of the Conformationally Controlled β–Turn Mimetic Torsion Balance Core Scaffold.  Master's Thesis, University of Pittsburgh.    (Unpublished)