?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F33990%2F&rft.title=Synthesis+of+the+Conformationally+Controlled+%CE%B2%E2%80%93Turn+Mimetic+Torsion+Balance+Core+Scaffold&rft.creator=Lypson%2C+Alyssa+B.&rft.description=The+molecular+torsion+balance+concept+was+applied+to+a+new+conformationally+controlled+scaffold+to+accurately+evaluate+pairwise+amino+acid+interactions+in+an+antiparallel+%CE%B2-sheet+motif.+The+scaffold%E2%80%99s+core+design+combines+(ortho-tolyl)amide+and+o%2Co%2Co%E2%80%B2-trisubstituted+biphenyl+structural+units+to+provide+a+geometry+better-suited+for+intramolecular+hydrogen+bonding.++The+aim+of+this+study+was+to+develop+synthetic+methods+for+the+core+scaffold+and+to+conduct+a+preliminary+investigation+into+the+improved+sequence+alignment+on+upper+and+lower+aromatic+rings+to+promote+hydrogen+bond+formation+at+the+correct+distance+and+antiparallel+orientation.&rft.date=2018-06-14&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F33990%2F1%2FMS_Thesis_Alyssa_B_Lypson.pdf&rft.identifier=++Lypson%2C+Alyssa+B.++(2018)+Synthesis+of+the+Conformationally+Controlled+%CE%B2%E2%80%93Turn+Mimetic+Torsion+Balance+Core+Scaffold.++Master's+Thesis%2C+University+of+Pittsburgh.++++(Unpublished)++