%A Richard Liberatore
%T The Application of Ruthenium(II) and Iridium(I) Complexes to the Synthesis of Complex Organic Products
%X The application of transition metals to the synthesis complex organic products has become an extremely important facet of chemistry in the last few decades. Such metal complexes exhibit remarkable activity in the construction of new carbon-carbon or carbon-heteroatom bonds in both catalytic and asymmetric fashion. The advance in organometallic chemistry has allowed chemists to access new structural scaffolds while also minimizing the use of stoichiometric reagents. The document herein details the application of iridium(I) and ruthenium(II) complexes to the synthesis of complex organic products. Iridium(I) compounds display good activity in the chemoselective isomerization of di(allyl) ethers and carbonates to access allyl vinyl compounds which are classic substrates for Claisen rearrangements. Ruthenium(II) catalysis can provide ?,?-substituted-?,?-unsaturated aldehydes and amides from allyl vinyl species such as allyl vinyl ethers, carbonatres, silyl enol ethers and allyl acetates. Our methodology was utilized in the construction of the active core of a potential cancer therapeutic, actinoranone.
%D 2018
%K organic synnthesis, ruthenium catalysis, asymmetric catalysis, natural product synthesis
%I University of Pittsburgh
%L pittir33679