<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "DEVELOPMENT OF A NEW ENANTIOSELECTIVE REDUCTION OF KETONE AND FLUOROGENIC DETECTION OF HYDROGEN PEROXIDE"^^ . "Aberrant splicing related mutations are related to many diseases including cancers while reactive oxygen species (ROS) imbalance is linked to oxidative cellular damage, ultimately leading to aging and neurodegenerative illness. ROS is also known to protect the cells from foreign pathogens due to their oxidative nature. Herein we have taken two different approaches to study them. \r\nIn the first chapter, we discuss an improved synthesis of meayamycins, that are powerful modulators of the spliceosome and are used as tools to study splicing mutations. We examined a new enantioselective reduction of prochiral ketone, en route to the synthesis of meayamycin B. We also described the synthesis of new analogue keto-meayamycin D that probes the potency of meayamycins containing other electrophilic functionalities instead of the epoxide group. \r\nIn the second chapter, we discussed the need for new fluorescent turn-on probes for a better understanding of how ROS participates in cellular processes. We describe the syntheses of two new probes for the detection of H2O2 that is based on a Mislow-Evans rearrangement. We further studied the stability and kinetics in detail and how they could be beneficial in complimenting the existing probes. Finally, we examined the effect of serum on the Mislow-Evans rearrangement, which is the underlying principle for the H2O2 detection."^^ . "2018-01-31" . . . . . . . . "Upamanyu"^^ . "Basu"^^ . "Upamanyu Basu"^^ . . . . . . "DEVELOPMENT OF A NEW ENANTIOSELECTIVE REDUCTION OF KETONE AND FLUOROGENIC DETECTION OF HYDROGEN PEROXIDE (PDF)"^^ . . . "DEVELOPMENT OF A NEW ENANTIOSELECTIVE REDUCTION OF KETONE AND FLUOROGENIC DETECTION OF HYDROGEN PEROXIDE (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "DEVELOPMENT OF A NEW ENANTIOSELECTIVE REDUCTION OF KETONE AND FLUOROGENIC DETECTION OF HYDROGEN PEROXIDE (Other)"^^ . . . . . . "preview.jpg"^^ . . . "DEVELOPMENT OF A NEW ENANTIOSELECTIVE REDUCTION OF KETONE AND FLUOROGENIC DETECTION OF HYDROGEN PEROXIDE (Other)"^^ . . . . . . "medium.jpg"^^ . . . "DEVELOPMENT OF A NEW ENANTIOSELECTIVE REDUCTION OF KETONE AND FLUOROGENIC DETECTION OF HYDROGEN PEROXIDE (Other)"^^ . . . . . . "small.jpg"^^ . . . "DEVELOPMENT OF A NEW ENANTIOSELECTIVE REDUCTION OF KETONE AND FLUOROGENIC DETECTION OF HYDROGEN PEROXIDE (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #33406 \n\nDEVELOPMENT OF A NEW ENANTIOSELECTIVE REDUCTION OF KETONE AND FLUOROGENIC DETECTION OF HYDROGEN PEROXIDE\n\n" . "text/html" . .