eprintid: 33175
rev_number: 7
userid: 6615
dir: disk0/00/03/31/75
datestamp: 2018-01-30 19:00:17
lastmod: 2018-01-30 19:00:17
status_changed: 2018-01-30 19:00:17
type: thesis_degree
metadata_visibility: show
contact_email: gordoncfchiu@gmail.com
eprint_status: archive
creators_name: Chiu, Cheuk Fai
creators_email: gordoncfchiu@gmail.com
creators_id: Chc151
title: NANO EMITTERS: FLUORIMETRIC ANALYSIS OF SINGLE-WALLED CARBON NANOTUBES IN BIO-OXIDATION
ispublished: unpub
divisions: sch_as_chemistry
full_text_status: public
keywords: Carbon Nanotube, Bioxidation, Enzyme, fatty acid, photoluminescence
abstract: Carbon nanotubes have remarkable electrical, mechanical and optical properties. They have been employed for applications such as electronics, sensors, composite materials and solar cells. One developing application is biomedical imaging and nanomedicine. For these in vivo applications, the interactions between carbon nanotubes and biomolecules are particularly important.

This dissertation will guide the reader through the recent studies of bio-oxidations of single-walled carbon nanotubes (SWCNTs). The enzyme-catalyzed oxidation of SWCNTs will be examined using photoluminescence spectroscopy. The analysis of photoluminescence data will extend the understanding of enzymatic oxidation of SWCNTs to include CNTs of different diameters and geometries. The mechanism of these processes will be discussed. The enzyme-shortened SWCNTs may find application in cellular imaging and drug delivery systems. Furthermore, the effect of CNT coatings on bio-oxidation will be studied. Surfactants and biomolecules that protect SWCNTs from enzymatic degradation will be identified. The findings will provide an important insight into the mechanism of bio-degradation of coated-nanotubes, and can be applied and extended to other nanomaterials and nano-emitters.

Finally, reaction between SWCNTs and polyunsaturated fatty acids will be examined. Reaction mechanism will be established and products identified. The reaction of interest will provide a new understanding of SWCNT-lipid interactions, and can be potentially used for in vivo lipid peroxidation detection.
date: 2018-01-30
date_type: published
pages: 191
institution: University of Pittsburgh
refereed: TRUE
etdcommittee_type: committee_chair
etdcommittee_type: committee_member
etdcommittee_type: committee_member
etdcommittee_type: committee_member
etdcommittee_name: Star, Alexander
etdcommittee_name: Liu, Haitao
etdcommittee_name: Robinson, Renã A. S.
etdcommittee_name: Islam, Mohammad F.
etdcommittee_email: astar@pitt.edu
etdcommittee_email: hliu@pitt.edu
etdcommittee_email: rena@pitt.edu
etdcommittee_email: mohammad@cmu.edu
etd_defense_date: 2017-08-30
etd_approval_date: 2018-01-30
etd_submission_date: 2017-09-01
etd_release_date: 2018-01-30
etd_access_restriction: immediate
etd_patent_pending: FALSE
thesis_type: dissertation
degree: PhD
citation:   Chiu, Cheuk Fai  (2018) NANO EMITTERS: FLUORIMETRIC ANALYSIS OF SINGLE-WALLED CARBON NANOTUBES IN BIO-OXIDATION.  Doctoral Dissertation, University of Pittsburgh.    (Unpublished)  
document_url: http://d-scholarship-dev.library.pitt.edu/33175/1/Dissertation_chiu.pdf