?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F33175%2F&rft.title=NANO+EMITTERS%3A+FLUORIMETRIC+ANALYSIS+OF+SINGLE-WALLED+CARBON+NANOTUBES+IN+BIO-OXIDATION&rft.creator=Chiu%2C+Cheuk+Fai&rft.description=Carbon+nanotubes+have+remarkable+electrical%2C+mechanical+and+optical+properties.+They+have+been+employed+for+applications+such+as+electronics%2C+sensors%2C+composite+materials+and+solar+cells.+One+developing+application+is+biomedical+imaging+and+nanomedicine.+For+these+in+vivo+applications%2C+the+interactions+between+carbon+nanotubes+and+biomolecules+are+particularly+important.%0D%0A%0D%0AThis+dissertation+will+guide+the+reader+through+the+recent+studies+of+bio-oxidations+of+single-walled+carbon+nanotubes+(SWCNTs).+The+enzyme-catalyzed+oxidation+of+SWCNTs+will+be+examined+using+photoluminescence+spectroscopy.+The+analysis+of+photoluminescence+data+will+extend+the+understanding+of+enzymatic+oxidation+of+SWCNTs+to+include+CNTs+of+different+diameters+and+geometries.+The+mechanism+of+these+processes+will+be+discussed.+The+enzyme-shortened+SWCNTs+may+find+application+in+cellular+imaging+and+drug+delivery+systems.+Furthermore%2C+the+effect+of+CNT+coatings+on+bio-oxidation+will+be+studied.+Surfactants+and+biomolecules+that+protect+SWCNTs+from+enzymatic+degradation+will+be+identified.+The+findings+will+provide+an+important+insight+into+the+mechanism+of+bio-degradation+of+coated-nanotubes%2C+and+can+be+applied+and+extended+to+other+nanomaterials+and+nano-emitters.%0D%0A%0D%0AFinally%2C+reaction+between+SWCNTs+and+polyunsaturated+fatty+acids+will+be+examined.+Reaction+mechanism+will+be+established+and+products+identified.+The+reaction+of+interest+will+provide+a+new+understanding+of+SWCNT-lipid+interactions%2C+and+can+be+potentially+used+for+in+vivo+lipid+peroxidation+detection.&rft.date=2018-01-30&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F33175%2F1%2FDissertation_chiu.pdf&rft.identifier=++Chiu%2C+Cheuk+Fai++(2018)+NANO+EMITTERS%3A+FLUORIMETRIC+ANALYSIS+OF+SINGLE-WALLED+CARBON+NANOTUBES+IN+BIO-OXIDATION.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++