eprintid: 32479
rev_number: 29
userid: 6890
dir: disk0/00/03/24/79
datestamp: 2017-10-26 19:46:52
lastmod: 2020-07-01 05:15:05
status_changed: 2017-10-26 19:46:52
type: thesis
succeeds: 32362
metadata_visibility: show
contact_email: tthompson086@gmail.com
item_issues_id: thesis_degree_versioning
item_issues_type: thesis_degree_versioning
item_issues_description: ETD 32479 is using versioning.
item_issues_timestamp: 2017-06-20 06:01:55
item_issues_status: autoresolved
item_issues_count: 0
eprint_status: archive
creators_name: Thompson, Tiffany
creators_email: tmt53@pitt.edu
creators_id: tmt53
contributors_type: committee_chair
contributors_type: committee_member
contributors_type: committee_member
contributors_name: Hartman, Amy
contributors_name: Mattila, Joshua
contributors_name: Oury, Tim
contributors_email: hartman2@pit.edu
contributors_email: jmattila@pitt.edu
contributors_email: tdoury@pitt.edu
contributors_id: hartman2
contributors_id: jmattila
contributors_id: tdoury
title: A literature review of the histology of Rift Valley Fever virus neurological disease comparing rodent and NHP models to human disease
ispublished: pub
divisions: sch_gsph_infectiousdiseasesmicrobiology
full_text_status: public
keywords: Rift Valley Fever, RVFV, RVF, Histology, Animal models
abstract: Rift Valley Fever Virus (RVFV) is an arbovirus most commonly spread through mosquitos or infected animal tissues, and can infect a wide range of animals with the biggest impact being on ruminants and humans. RVFV is a major concern for possible spread into the America’s as well as it being used as a biological weapon due to the high mortality rate associated with aerosolizing the virus. This review will focus on the neurological disease seen in the developed animal models and the histology being used in the research of RVFV. The first model developed was the mouse model and is most useful because of the developed knockouts in mice. Certain mice can consistently produce neurological disease through intranasal infection, and histological examination of brain tissue shows widespread encephalitis. Rat models are also being used to a lesser extent but have some benefits of consistently reproducing neurological disease and studying the genetic aspects of RVFV. Rat models reproduce meningoencephalitis which more closely mimics human neurological disease. Non-human primate (NHP) models are most applicable to human disease and African green monkey (AGM) as well as marmosets have been shown to be susceptible to RVFV infection. The public health significance of RVFV is the possibility of spread to United States and severe disruption in agriculture as well as the possible use as a biological weapon.
date: 2017-06-23
date_type: submitted
pages: 38
institution: University of Pittsburgh
refereed: TRUE
etd_defense_date: 2017
etd_submission_date: 2017-06-05
etd_access_restriction: immediate
etd_patent_pending: FALSE
thesis_type: masteressay
degree: MPH
citation:   Thompson, Tiffany  (2017) A literature review of the histology of Rift Valley Fever virus neurological disease comparing rodent and NHP models to human disease.  Master Essay, University of Pittsburgh.   
document_url: http://d-scholarship-dev.library.pitt.edu/32479/1/Thompson%20Lit%20Review%206_2017.doc