eprintid: 31585
rev_number: 128
userid: 6632
dir: disk0/00/03/15/85
datestamp: 2017-07-13 19:35:57
lastmod: 2021-07-02 12:56:07
status_changed: 2017-07-13 19:35:57
type: thesis
succeeds: 31584
metadata_visibility: show
contact_email: corrinebozich@yahoo.com
eprint_status: archive
creators_name: Bozich, Corrine
creators_email: cnb31@pitt.edu
creators_id: CNB31
contributors_type: committee_chair
contributors_type: committee_member
contributors_type: committee_member
contributors_name: Martinson, Jeremy
contributors_name: Haggerty, Catherine
contributors_name: Yassin, Mohamed
contributors_email: jmartins@pitt.edu
contributors_email: HaggertyC@edc.pitt.edu
contributors_email: yassinm@upmc.edu
contributors_id: jmartins
contributors_id: haggerty
contributors_id: MHY8
title: A case control study of risk factors associated with CRE/CRO and ESBL
ispublished: unpub
divisions: sch_gsph_infectiousdiseasesmicrobiology
full_text_status: public
abstract: Antibiotic resistance is a growing problem that affects public health. Antibiotic resistance is prominent at large medical centers with complicated medical care and need for prolonged use of broad spectrum antibiotics. Multi-drug resistant Gram negative rods (GNR-MDRO) are a group of bacteria that pose a particular threat, as they cause life-threatening infections with limited options for treatment. This is a case-control study that aims at answering questions regarding MDRO origin and risk factors. We are including in this study three types of MDRO; Extended-spectrum β-lactamases (ESBL) (used as the control), Carbapenem-Resistant Enterobactericiae (CRE) and other Carbapenem-Resistant Organisms (CRO) such as lactose non-ferments (mostly Pseudomonas and Acinetobacter). Factors such as indwelling urinary or intravenous catheter upon admission, tracheostomy/ventilator, and chronic wound were found to be significant in a univariate analysis, however, only chronic wound presence (OR: 5.58; 95% CI: 1.87-16.63) and history of tracheostomy/ventilator (OR: 27.06; 95% CI: 3.20-229.15) were significant after entry into a multivariable logistic regression model, meaning that the presence of a chronic wound and/or history of tracheostomy/ventilator is associated with MDRO colonization, specifically CRE/CRO. Hospitals should practice extra care with patients with a chronic wound and/or with a history of a tracheostomy or being on a mechanical ventilator. These patients should be screened for CRE/CRO both upon admission and during their hospital stay in order to provide optimal prevention of CRE colonization and spread.
date: 2017-04-01
date_type: submitted
publisher: University of Pittsburgh
institution: University of Pittsburgh
refereed: TRUE
thesis_type: masteressay
degree: MPH
citation:   Bozich, Corrine  (2017) A case control study of risk factors associated with CRE/CRO and ESBL.  Master Essay, University of Pittsburgh.   
document_url: http://d-scholarship-dev.library.pitt.edu/31585/1/BozichC_MastersEssay_April2017.doc
document_url: http://d-scholarship-dev.library.pitt.edu/31585/3/licence.txt