<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "SYNTHETIC STUDIES ON PROTEIN KINASE D, BOTULINUM NEUROTOXIN A1 LIGHT CHAIN, AND NUCLEAR ANDROGEN RECEPTOR MODULATORS, AND EFFORTS TOWARDS THE TOTAL SYNTHESIS OF 9-DESMETHYLPLEUROTIN"^^ . "The first chapter outlines the synthesis of pyrazolo[3,4-d]pyrimidines as inhibitors of Protein Kinase D, a potential target for cancer therapy. The second chapter describes the synthesis of novel inhibitors of Botulinum Neurotoxin A1. First, the synthesis of a constrained analog that contains a dibenzo[b,g][1,5]thiazocine is discussed. Second, we explore the use of a Staudinger aza-Wittig reaction to produce 1,2,4-triazines and report the progress towards an inhibitor of BoNT/A with increased metabolic stability.\r\nThe third chapter describes the development of antagonists of the androgen receptor, a potential target for the treatment of castration-resistant prostate cancer. A small library of analogs was synthesized to assess a structure-activity relationship of a hit compound. The new lead compound was tested in vivo and further optimized to improve its metabolic stability. This chapter also describes the synthesis of small molecule affinity labeled conjugates to identify the mechanism of action of the antagonists. The final chapter of this dissertation describes the progress towards the total synthesis of 9-desmethylpleurotin."^^ . "2017-09-29" . . . . . . . . "James"^^ . "Johnson"^^ . "James Johnson"^^ . . . . . . "SYNTHETIC STUDIES ON PROTEIN KINASE D, BOTULINUM NEUROTOXIN A1 LIGHT CHAIN, AND NUCLEAR ANDROGEN RECEPTOR MODULATORS, AND EFFORTS TOWARDS THE TOTAL SYNTHESIS OF 9-DESMETHYLPLEUROTIN (PDF)"^^ . . . "James_K_Johnson_3.5.2_ETD2017.pdf"^^ . . . "SYNTHETIC STUDIES ON PROTEIN KINASE D, BOTULINUM NEUROTOXIN A1 LIGHT CHAIN, AND NUCLEAR ANDROGEN RECEPTOR MODULATORS, AND EFFORTS TOWARDS THE TOTAL SYNTHESIS OF 9-DESMETHYLPLEUROTIN (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "SYNTHETIC STUDIES ON PROTEIN KINASE D, BOTULINUM NEUROTOXIN A1 LIGHT CHAIN, AND NUCLEAR ANDROGEN RECEPTOR MODULATORS, AND EFFORTS TOWARDS THE TOTAL SYNTHESIS OF 9-DESMETHYLPLEUROTIN (Other)"^^ . . . . . . "preview.jpg"^^ . . . "SYNTHETIC STUDIES ON PROTEIN KINASE D, BOTULINUM NEUROTOXIN A1 LIGHT CHAIN, AND NUCLEAR ANDROGEN RECEPTOR MODULATORS, AND EFFORTS TOWARDS THE TOTAL SYNTHESIS OF 9-DESMETHYLPLEUROTIN (Other)"^^ . . . . . . "medium.jpg"^^ . . . "SYNTHETIC STUDIES ON PROTEIN KINASE D, BOTULINUM NEUROTOXIN A1 LIGHT CHAIN, AND NUCLEAR ANDROGEN RECEPTOR MODULATORS, AND EFFORTS TOWARDS THE TOTAL SYNTHESIS OF 9-DESMETHYLPLEUROTIN (Other)"^^ . . . . . . "small.jpg"^^ . . . "SYNTHETIC STUDIES ON PROTEIN KINASE D, BOTULINUM NEUROTOXIN A1 LIGHT CHAIN, AND NUCLEAR ANDROGEN RECEPTOR MODULATORS, AND EFFORTS TOWARDS THE TOTAL SYNTHESIS OF 9-DESMETHYLPLEUROTIN (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #30984 \n\nSYNTHETIC STUDIES ON PROTEIN KINASE D, BOTULINUM NEUROTOXIN A1 LIGHT CHAIN, AND NUCLEAR ANDROGEN RECEPTOR MODULATORS, AND EFFORTS TOWARDS THE TOTAL SYNTHESIS OF 9-DESMETHYLPLEUROTIN\n\n" . "text/html" . .