eprintid: 29831
rev_number: 21
userid: 5901
dir: disk0/00/02/98/31
datestamp: 2016-10-11 18:26:09
lastmod: 2019-02-04 15:56:21
status_changed: 2016-10-11 18:26:09
type: article
metadata_visibility: show
eprint_status: archive
creators_name: Flint, MS
creators_name: Bovbjerg, DH
creators_email: msf10@pitt.edu
creators_email: dhb15@pitt.edu
creators_id: MSF10
creators_id: DHB15
title: DNA damage as a result of psychological stress: implications for breast cancer
ispublished: pub
divisions: sch_as_psychology
divisions: sch_gsph_behavioralcommhealthsci
divisions: sch_med_Pharmacology_Chemical_Biology
divisions: sch_med_Psychiatry
full_text_status: public
abstract: Accumulating evidence indicates that psychological stress can have deleterious influences on cancer development and progression, but the mechanisms responsible remain unclear. One possible mechanism is suggested by emerging evidence that DNA damage is increased by exposure to stress and stress hormones (for example, cortisol, catecholamines). Possible molecular mechanisms for such effects were the subject of a recent paper by Hara and colleagues, which suggests that chronic stress, through β-adrenergic stimulation, can induce two synergistic pathways that result in accumulation of DNA damage. Herein, we discuss the potential implications of these findings for breast cancer etiology, progression, and treatment response. © 2012 BioMed Central Ltd.
date: 2012-09-21
date_type: published
publication: Breast Cancer Research
volume: 14
number: 5
refereed: TRUE
issn: 1465-5411
centers: cen_other_pittcancerinst
id_number: 10.1186/bcr3189
citation:   Flint, MS and Bovbjerg, DH  (2012) DNA damage as a result of psychological stress: implications for breast cancer.  Breast Cancer Research, 14 (5).   ISSN 1465-5411     
document_url: http://d-scholarship-dev.library.pitt.edu/29831/1/art%253A10.1186%252Fbcr3189.pdf
document_url: http://d-scholarship-dev.library.pitt.edu/29831/7/licence.txt