relation: http://d-scholarship-dev.library.pitt.edu/28938/
title: The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles
creator: Tarabichi, Y
creator: Li, K
creator: Hu, S
creator: Nguyen, C
creator: Wang, X
creator: Elashoff, D
creator: Saira, K
creator: Frank, B
creator: Bihan, M
creator: Ghedin, E
creator: Methé, BA
creator: Deng, JC
description: BACKGROUND: Viral infections such as influenza have been shown to predispose hosts to increased colonization of the respiratory tract by pathogenic bacteria and secondary bacterial pneumonia. To examine how viral infections and host antiviral immune responses alter the upper respiratory microbiota, we analyzed nasal bacterial composition by 16S ribosomal RNA (rRNA) gene sequencing in healthy adults at baseline and at 1 to 2 weeks and 4 to 6 weeks following instillation of live attenuated influenza vaccine or intranasal sterile saline. A subset of these samples was submitted for microarray host gene expression profiling.
date: 2015-12-15
type: Article
type: PeerReviewed
format: application/pdf
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/28938/1/art%253A10.1186%252Fs40168-015-0133-2.pdf
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/28938/7/licence.txt
identifier:   Tarabichi, Y and Li, K and Hu, S and Nguyen, C and Wang, X and Elashoff, D and Saira, K and Frank, B and Bihan, M and Ghedin, E and Methé, BA and Deng, JC  (2015) The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles.  Microbiome, 3.  74 - ?.      
relation: 10.1186/s40168-015-0133-2