eprintid: 27887
rev_number: 20
userid: 5682
dir: disk0/00/02/78/87
datestamp: 2016-06-29 19:36:03
lastmod: 2019-05-01 05:15:12
status_changed: 2016-06-29 19:36:03
type: thesis_degree
metadata_visibility: show
contact_email: cas0586@hotmail.com
item_issues_count: 0
eprint_status: archive
creators_name: Archibald, Crystal
creators_email: cas0586@hotmail.com
creators_id: CRS117
title: Comparing the immunogenicity of influenza vaccines LAIV and IIV in pediatric patients during the 2014-2015 season
ispublished: unpub
divisions: sch_gsph_infectiousdiseasesmicrobiology
full_text_status: public
keywords: Influenza Vaccine
abstract: Influenza virus causes a contagious respiratory illness in humans that poses a major public health threat, especially to vulnerable populations such as children and adolescents, who have less mature immune systems. Influenza infections are responsible for over 200,000 hospitalizations and over 3,600 deaths a year.  The influenza vaccine is the best form of prevention from influenza illness due to the vaccines ability to elicit an antibody response without causing illness.  Currently, there are two types of influenza vaccines available to children and adolescents, the inactivated influenza vaccine (IIV) and the live attenuated influenza vaccine (LAIV). The present study was designed to compare the immunogenicity of the two vaccines in pediatric participant’s ages 3 to 17 years. We hypothesized that the LAIV vaccine would produce an increased breath and enhanced antibody response to influenza vaccination compared to the IIV vaccine.  Results from this study suggest that IIV was superior compared to LAIV at eliciting immune responses following vaccination.  However, potential limitations include the fact that current assays measure immune responses in peripheral blood only and may not reflect mucosal immunity. Further, due to issues with the H1N1 virus strain in the LAIV vaccine, these results need to be confirmed in a season where LAIV vaccine is immunogenic (2015-16).
date: 2016-06-29
date_type: published
pages: 59
institution: University of Pittsburgh
refereed: TRUE
etdcommittee_type: committee_chair
etdcommittee_type: committee_member
etdcommittee_type: committee_member
etdcommittee_name: Cole, Kelly Stefano
etdcommittee_name: Barratt-Boyes, Simon M
etdcommittee_name: Ayyavoo, Velpandi
etdcommittee_email: stefcole@pitt.edu
etdcommittee_email: smbb@pitt.edu
etdcommittee_email: velpandi@pitt.edu
etdcommittee_id: STEFCOLE
etdcommittee_id: SMBB
etdcommittee_id: VELPANDI
etd_defense_date: 2016-01-08
etd_approval_date: 2016-06-29
etd_submission_date: 2016-04-28
etd_release_date: 2016-06-29
etd_access_restriction: 3_year
etd_patent_pending: FALSE
thesis_type: thesis
degree: MPH
citation:   Archibald, Crystal  (2016) Comparing the immunogenicity of influenza vaccines LAIV and IIV in pediatric patients during the 2014-2015 season.  Master's Thesis, University of Pittsburgh.    (Unpublished)  
document_url: http://d-scholarship-dev.library.pitt.edu/27887/1/CAArchibald_MPHthesis_4_2016.pdf