relation: http://d-scholarship-dev.library.pitt.edu/27887/
title: Comparing the immunogenicity of influenza vaccines LAIV and IIV in pediatric patients during the 2014-2015 season
creator: Archibald, Crystal
description: Influenza virus causes a contagious respiratory illness in humans that poses a major public health threat, especially to vulnerable populations such as children and adolescents, who have less mature immune systems. Influenza infections are responsible for over 200,000 hospitalizations and over 3,600 deaths a year.  The influenza vaccine is the best form of prevention from influenza illness due to the vaccines ability to elicit an antibody response without causing illness.  Currently, there are two types of influenza vaccines available to children and adolescents, the inactivated influenza vaccine (IIV) and the live attenuated influenza vaccine (LAIV). The present study was designed to compare the immunogenicity of the two vaccines in pediatric participant’s ages 3 to 17 years. We hypothesized that the LAIV vaccine would produce an increased breath and enhanced antibody response to influenza vaccination compared to the IIV vaccine.  Results from this study suggest that IIV was superior compared to LAIV at eliciting immune responses following vaccination.  However, potential limitations include the fact that current assays measure immune responses in peripheral blood only and may not reflect mucosal immunity. Further, due to issues with the H1N1 virus strain in the LAIV vaccine, these results need to be confirmed in a season where LAIV vaccine is immunogenic (2015-16).
date: 2016-06-29
type: University of Pittsburgh ETD
type: PeerReviewed
format: application/pdf
language: en
identifier: http://d-scholarship-dev.library.pitt.edu/27887/1/CAArchibald_MPHthesis_4_2016.pdf
identifier:   Archibald, Crystal  (2016) Comparing the immunogenicity of influenza vaccines LAIV and IIV in pediatric patients during the 2014-2015 season.  Master's Thesis, University of Pittsburgh.    (Unpublished)