<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Total synthesis of (±)-nisamycin"^^ . "We have developed a highly convergent synthesis of the manumycin-type m- C7N-antibiotic nisamycin that is applicable to other members of this family of antibiotics. The synthesis features a three-step sequence to the epoxyquinol core that serves as a scaffold for the attachment of the polyene side chains. The eastern polyene side chain was constructed via a novel organozirconocene-mediated synthesis. Zirconocene methodology was also applied to the synthesis of the polyene side chains of asukamycin. The southern side chain of nisamycin was introduced via a Stille reaction that employed a vinyl bromo ketone, derived from an acid-sensitive bromo ketal. Pd-mediated coupling of the vinyl bromide with a stannyl TIPS ester gave TIPS-protected nisamycin that was readily converted to the natural product."^^ . "1999-07-09" . . "64" . "14" . . "Journal of Organic Chemistry"^^ . . . "00223263" . . . . . . . . . . "P"^^ . "Wipf"^^ . "P Wipf"^^ . . "PDG"^^ . "Coish"^^ . "PDG Coish"^^ . . . . . . "Total synthesis of (±)-nisamycin (Plain Text)"^^ . . . "licence.txt"^^ . . . "Total synthesis of (±)-nisamycin (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #25623 \n\nTotal synthesis of (±)-nisamycin\n\n" . "text/html" . .