<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells"^^ . "ABT-737 inhibits the anti-apoptotic proteins B-cell lymphoma 2 (BCL-2) and BCL-X L. Meayamycin B switches the splicing pattern of myeloid cell leukemia factor 1 (MCL1) pre-mRNA. Specifically, inhibition of splicing factor 3B subunit 1 (SF3B1) with meayamycin B promotes the generation of the proapoptotic, short splicing variant (MCL1-S) and diminishes the antiapoptotic, long variant (MCL1-L). This action was previously associated with the cytotoxicity of meayamycin B in non-small cell lung carcinoma cell lines. ABT-737 induced apoptosis in response to an ablation of MCL1-L by meayamycin B. In this study, we further exploited this synergistic combination in head and neck squamous cell carcinoma (HNSCC), up to 90% of which overexpress MCL1 and BCL-X L. In a panel of seven HNSCC cell lines, the combination of meayamycin B and ABT-737 rapidly triggered a Bax/Bak-mediated apoptosis that overcame the resistance from HPV16-positive HNSCC against each agent alone. Both RT-PCR and Western blotting showed that meayamycin B up-regulated MCL1-S and down-regulated MCL1-L. Significantly, we discovered that SF3B1 was involved in the splicing of oncogenic HPV16 E6 to produce non-oncogenic HPV16 E6*, indicating that SF3B1 may inhibit HPV16-induced tumorigenesis."^^ . "2014-08-20" . . . "4" . . "Scientific Reports"^^ . . . . . . . . . . . . . . . . . "RL"^^ . "Ferris"^^ . "RL Ferris"^^ . . "Y"^^ . "Gao"^^ . "Y Gao"^^ . . "K"^^ . "Koide"^^ . "K Koide"^^ . . "S"^^ . "Trivedi"^^ . "S Trivedi"^^ . . . . . . "Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells (PDF)"^^ . . . . . . . . . . . "srep06098.pdf"^^ . . . "Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells (Image (JPEG))"^^ . . . . . . "preview.jpg"^^ . . . "Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . . "Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells (Plain Text)"^^ . . . "licence.txt"^^ . . . "Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #24135 \n\nRegulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells\n\n" . "text/html" . .