?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F24062%2F&rft.title=PEPTIDE-BASED+METHODS+FOR+ASSEMBLING+AND+CONTROLLING+THE+MORPHOLOGIES%2C+METRICS%2C+AND+PROPERTIES+OF+GOLD+NANOPARTICLE+SUPERSTRUCTURES&rft.creator=Zhang%2C+Chen&rft.description=This+dissertation+describes+new+peptide-based+methods+for+assembling+and+controlling+the+morphologies%2C+metrics%2C+and+properties+of+gold+nanoparticle+superstructures.+The+aim+of+this+research+is+to+develop+the+peptide-based+method+by+modifying+the+peptide+sequences+and+controlling+the+reaction+conditions+for+the+synthesis+and+assembly+of+gold+nanoparticle+superstructures+to+achieve+reliable+control+over+their+morphology+and+metrics%2C+and+furthermore+study+their+properties+and+applications.%0D%0AWith+this+goal+in+mind%2C+the+C-terminus+of+a+gold-binding+peptide+was+modified+with+different+numbers+of+hydrophobic+phenylalanines+to+affect+peptide+assembly+and+ultimately+nanoparticle+assembly.+The+addition+of+hydrophobic+phenylalanines+to+the+C-terminus+of+peptide+conjugates+promoted+fiber+bundling+which+in+turn+lead+to+the+formation+of+thick+or+intertwined+1-D+nanoparticle+superstructures.+Furthermore%2C+I+prepared+spherical+gold+nanoparticle+superstructures+with+varied+diameters+(~40nm%2C+~75nm%2C+and+~150nm)+and+visible+to+near-infrared+optical+properties+by+using+a+single+peptide+conjugate+molecule+yet+varied+reaction+conditions.+Theoretical+simulation+and+experiment+were+coupled+to+further+understand+their+optical+properties.+Finally%2C+I+studied+and+demonstrated+the+drug+storage+and+release+properties+of+hollow+spherical+gold+nanoparticle+superstructures%3B+this+was+the+first+demonstrated+application+of+this+class+of+nanoparticle+superstructure.%0D%0A&rft.date=2015-06-23&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F24062%2F1%2FPhD_Dissertation__Chen_Zhang_3.pdf&rft.identifier=++Zhang%2C+Chen++(2015)+PEPTIDE-BASED+METHODS+FOR+ASSEMBLING+AND+CONTROLLING+THE+MORPHOLOGIES%2C+METRICS%2C+AND+PROPERTIES+OF+GOLD+NANOPARTICLE+SUPERSTRUCTURES.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++