?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F23857%2F&rft.title=Distributed+Spectral+Graph+Methods+for+Analyzing+Large-Scale+Unstructured+Biomedical+Data&rft.creator=Quinn%2C+Shannon&rft.description=There+is+an+ever-expanding+body+of+biological+data%2C+growing+in+size+and+complexity%2C+out-+stripping+the+capabilities+of+standard+database+tools+or+traditional+analysis+techniques.+Such+examples+include+molecular+dynamics+simulations%2C+drug-target+interactions%2C+gene+regulatory+networks%2C+and+high-throughput+imaging.+Large-scale+acquisition+and+curation+biological+data+has+already+yielded+results+in+the+form+of+lower+costs+for+genome+sequencing+and+greater+cov-+erage+in+databases+such+as+GenBank%2C+and+is+viewed+as+the+future+of+biocuration.+The+%E2%80%9Cbig+data%E2%80%9D+philosophy+and+its+associated+paradigms+and+frameworks+have+the+potential+to+uncover+solutions+to+problems+otherwise+intractable+with+more+traditional+investigative+techniques.%0D%0AHere%2C+we+focus+on+two+biological+systems+whose+data+form+large%2C+undirected+graphs.+First%2C+we+develop+a+quantitative+model+of+ciliary+motion+phenotypes%2C+using+spectral+graph+methods+for+unsupervised+latent+pattern+discovery.+Second%2C+we+apply+similar+techniques+to+identify+a+mapping+between+physiochemical+structure+and+odor+percept+in+human+olfaction.+In+both+cases%2C+we+experienced+computational+bottlenecks+in+our+statistical+machinery%2C+necessitating+the+creation+of+a+new+analysis+framework.+At+the+core+of+this+framework+is+a+distributed+hierarchical+eigensolver%2C+which+we+compare+directly+to+other+popular+solvers.+We+demon-+strate+its+essential+role+in+enabling+the+discovery+of+novel+ciliary+motion+phenotypes+and+in+identifying+physiochemical-perceptual+associations.&rft.date=2014-12-17&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F23857%2F1%2FSPQ_ETD.pdf&rft.identifier=++Quinn%2C+Shannon++(2014)+Distributed+Spectral+Graph+Methods+for+Analyzing+Large-Scale+Unstructured+Biomedical+Data.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++