relation: http://d-scholarship-dev.library.pitt.edu/22306/
title: Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome
creator: Goff, JP
creator: Epperly, MW
creator: Dixon, T
creator: Wang, H
creator: Franicola, D
creator: Shields, D
creator: Wipf, P
creator: Li, S
creator: Gao, X
creator: Greenberger, JS
description: Background/Aim: Total-body irradiation (TBI) doses in the range of 2-8 Gy are associated with a drop in peripheral blood counts, decreased bone marrow cellularity, and hematopoietic syndrome. Radiation mitigators must be safe for individuals likely to recover spontaneously. Materials and Methods: Female C57BL/6HNsd mice exposed to 9.0 and 9.15 Gy TBI, received intraperitoneal (10 mg/kg) JP4-039, a novel radiation mitigator, 24 hours after irradiation and were followed for hematopoietic recovery. Results: Irradiated mice showed reduced peripheral blood lymphocytes and neutrophils and bone marrow cellularity at day 5. Serum electrolytes, liver and renal function tests showed no deleterious effect of JP4-039-after irradiation, and no reduction in survival compared to irradiated controls. Marrow recovery measured as cellularity, and hematopoietic colony-forming cells including primitive granulocyte-erythroid-megakaryocyte- monocytes (GEMM), reached pre-irradiation levels by day 30 in JP4-039 treated groups. Mice receiving single or multiple administrations of JP4-039 showed an early return of CFU-GEMM. Conclusion: JP4-039 (GS-Nitroxide) is a safe radiation mitigator in mice warranting studies in larger animals and potentially a Phase I Clinical Trial.
date: 2011-01-01
type: Article
type: PeerReviewed
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/22306/1/licence.txt
identifier:   Goff, JP and Epperly, MW and Dixon, T and Wang, H and Franicola, D and Shields, D and Wipf, P and Li, S and Gao, X and Greenberger, JS  (2011) Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome.  In Vivo, 25 (3).  315 - 323.  ISSN 0258-851X