TY  - JOUR
ID  - pittir22178
UR  - http://d-scholarship-dev.library.pitt.edu/22178/
IS  - 1
A1  - Arnold, DM
A1  - Foster, C
A1  - Huryn, DM
A1  - Lazo, JS
A1  - Johnston, PA
A1  - Wipf, P
Y1  - 2007/01/01/
N2  - Mitogen-activated protein kinase phosphatase 1 is a tyrosine phosphatase superfamily member that dephosphorylates and inactivates mitogen-activated protein kinase substrates, such as p38, c-Jun-N-terminal kinase, and extracellular signal-related kinase. These mitogen-activated protein kinase substrates regulate many cellular processes associated with human diseases. In spite of this potential as a molecular target for chemotherapy, however, pharmacologically tractable inhibitors of mitogen-activated protein kinase phosphatase-1 have yet to be developed. Based on the results from a high-throughput screen for small molecule inhibitors of mitogen-activated protein kinase phosphatase-1, we designed, synthesized, and evaluated a focused library in an effort to further understand the structural requirements for mitogen-activated protein kinase phosphatase-1 inhibitory activity. © 2007 The Authors.
JF  - Chemical Biology and Drug Design
VL  - 69
SN  - 1747-0277
TI  - Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors
SP  - 23 
AV  - public
EP  -  30
ER  -