<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors"^^ . "Mitogen-activated protein kinase phosphatase 1 is a tyrosine phosphatase superfamily member that dephosphorylates and inactivates mitogen-activated protein kinase substrates, such as p38, c-Jun-N-terminal kinase, and extracellular signal-related kinase. These mitogen-activated protein kinase substrates regulate many cellular processes associated with human diseases. In spite of this potential as a molecular target for chemotherapy, however, pharmacologically tractable inhibitors of mitogen-activated protein kinase phosphatase-1 have yet to be developed. Based on the results from a high-throughput screen for small molecule inhibitors of mitogen-activated protein kinase phosphatase-1, we designed, synthesized, and evaluated a focused library in an effort to further understand the structural requirements for mitogen-activated protein kinase phosphatase-1 inhibitory activity. © 2007 The Authors."^^ . "2007-01-01" . . "69" . "1" . . "Chemical Biology and Drug Design"^^ . . . "17470277" . . . . . . . . . . . . . . . . . . . . . . "JS"^^ . "Lazo"^^ . "JS Lazo"^^ . . "DM"^^ . "Huryn"^^ . "DM Huryn"^^ . . "PA"^^ . "Johnston"^^ . "PA Johnston"^^ . . "C"^^ . "Foster"^^ . "C Foster"^^ . . "DM"^^ . "Arnold"^^ . "DM Arnold"^^ . . "P"^^ . "Wipf"^^ . "P Wipf"^^ . . . . . . "Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors (Plain Text)"^^ . . . "licence.txt"^^ . . . "Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #22178 \n\nSynthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors\n\n" . "text/html" . .