eprintid: 22177
rev_number: 16
userid: 1419
dir: disk0/00/02/21/77
datestamp: 2014-07-07 16:22:04
lastmod: 2019-02-02 15:55:26
status_changed: 2014-07-07 16:22:04
type: article
metadata_visibility: show
item_issues_count: 0
eprint_status: archive
creators_name: Kanai, A
creators_name: Zabbarova, I
creators_name: Amoscato, A
creators_name: Epperly, M
creators_name: Xiao, J
creators_name: Wipf, P
creators_email: 
creators_email: 
creators_email: aaa5@pitt.edu
creators_email: 
creators_email: 
creators_email: pwipf@pitt.edu
creators_id: 
creators_id: 
creators_id: AAA5
creators_id: 
creators_id: 
creators_id: PWIPF
title: Mitochondrial targeting of radioprotectants using peptidyl conjugates
ispublished: pub
divisions: sch_as_chemistry
full_text_status: public
abstract: Ionizing radiation activates a mitochondrial nitric oxide synthase, leading to inhibition of the respiratory chain, generation of excess superoxide, peroxynitrite production and nitrosative damage. We have measured the radioprotective effects of a nitric oxide synthase antagonist (AMT) versus a free radical scavenger (4-amino-TEMPO) using electrochemical detection of nitric oxide and peroxynitrite. To enhance their efficacy, we have conjugated these compounds to peptides and peptide isosteres - derived from the antibiotic gramicidin S - that target the mitochondria. The targeting ability of these peptidyl conjugates was measured using quantitative mass spectrometry. © The Royal Society of Chemistry.
date: 2007-01-01
date_type: published
publication: Organic and Biomolecular Chemistry
volume: 5
number: 2
pagerange: 307 - 309
refereed: TRUE
issn: 1477-0520
id_number: 10.1039/b613334g
other_id: NLM NIHMS264267
other_id: NLM PMC3032592
pmcid: PMC3032592
pmid: 17205174
mesh_headings: Animals
mesh_headings: Cyclic N-Oxides--chemistry
mesh_headings: Electrochemistry
mesh_headings: Gramicidin--chemistry
mesh_headings: Mass Spectrometry
mesh_headings: Mitochondria--metabolism
mesh_headings: Models, Chemical
mesh_headings: Nitric Oxide--chemistry
mesh_headings: Nitric Oxide Synthase--antagonists & inhibitors
mesh_headings: Peptides--chemistry
mesh_headings: Peroxynitrous Acid--chemistry
mesh_headings: Submitochondrial Particles--chemistry
mesh_headings: Superoxides
chemical_names: Cyclic N-Oxides
chemical_names: Peptides
chemical_names: Superoxides
chemical_names: Gramicidin
chemical_names: Peroxynitrous Acid
chemical_names: Nitric Oxide
chemical_names: Nitric Oxide Synthase
chemical_names: TEMPO
citation:   Kanai, A and Zabbarova, I and Amoscato, A and Epperly, M and Xiao, J and Wipf, P  (2007) Mitochondrial targeting of radioprotectants using peptidyl conjugates.  Organic and Biomolecular Chemistry, 5 (2).  307 - 309.  ISSN 1477-0520     
document_url: http://d-scholarship-dev.library.pitt.edu/22177/1/licence.txt