TY  - JOUR
ID  - pittir22177
UR  - http://d-scholarship-dev.library.pitt.edu/22177/
IS  - 2
A1  - Kanai, A
A1  - Zabbarova, I
A1  - Amoscato, A
A1  - Epperly, M
A1  - Xiao, J
A1  - Wipf, P
Y1  - 2007/01/01/
N2  - Ionizing radiation activates a mitochondrial nitric oxide synthase, leading to inhibition of the respiratory chain, generation of excess superoxide, peroxynitrite production and nitrosative damage. We have measured the radioprotective effects of a nitric oxide synthase antagonist (AMT) versus a free radical scavenger (4-amino-TEMPO) using electrochemical detection of nitric oxide and peroxynitrite. To enhance their efficacy, we have conjugated these compounds to peptides and peptide isosteres - derived from the antibiotic gramicidin S - that target the mitochondria. The targeting ability of these peptidyl conjugates was measured using quantitative mass spectrometry. © The Royal Society of Chemistry.
JF  - Organic and Biomolecular Chemistry
VL  - 5
SN  - 1477-0520
TI  - Mitochondrial targeting of radioprotectants using peptidyl conjugates
SP  - 307 
AV  - public
EP  -  309
ER  -