%0 Journal Article
%@ 1477-0520
%A Kanai, A
%A Zabbarova, I
%A Amoscato, A
%A Epperly, M
%A Xiao, J
%A Wipf, P
%D 2007
%F pittir:22177
%J Organic and Biomolecular Chemistry
%N 2
%P 307 - 309
%T Mitochondrial targeting of radioprotectants using peptidyl conjugates
%U http://d-scholarship-dev.library.pitt.edu/22177/
%V 5
%X Ionizing radiation activates a mitochondrial nitric oxide synthase, leading to inhibition of the respiratory chain, generation of excess superoxide, peroxynitrite production and nitrosative damage. We have measured the radioprotective effects of a nitric oxide synthase antagonist (AMT) versus a free radical scavenger (4-amino-TEMPO) using electrochemical detection of nitric oxide and peroxynitrite. To enhance their efficacy, we have conjugated these compounds to peptides and peptide isosteres - derived from the antibiotic gramicidin S - that target the mitochondria. The targeting ability of these peptidyl conjugates was measured using quantitative mass spectrometry. © The Royal Society of Chemistry.