eprintid: 22172
rev_number: 18
userid: 1419
dir: disk0/00/02/21/72
datestamp: 2014-07-18 21:08:18
lastmod: 2019-02-02 16:57:50
status_changed: 2014-07-18 21:08:18
type: article
metadata_visibility: show
item_issues_count: 0
eprint_status: archive
creators_name: Werner, S
creators_name: Turner, DM
creators_name: Lyon, MA
creators_name: Huryn, DM
creators_name: Wipf, P
creators_email: 
creators_email: 
creators_email: 
creators_email: 
creators_email: pwipf@pitt.edu
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: PWIPF
title: A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process
ispublished: pub
divisions: sch_as_chemistry
full_text_status: public
abstract: A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relationship studies of biological lead molecules. The tandem Biginelli-Ugi multi-component reaction facilitated the effective variation of four different substituents and allowed the synthesis of the library members in a sequence of only two one-pot reactions. © Georg Thieme Verlag Stuttgart.
date: 2006-09-01
date_type: published
publication: Synlett
number: 14
pagerange: 2334 - 2338
refereed: TRUE
issn: 0936-5214
id_number: 10.1055/s-2006-949648
citation:   Werner, S and Turner, DM and Lyon, MA and Huryn, DM and Wipf, P  (2006) A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process.  Synlett (14).  2334 - 2338.  ISSN 0936-5214     
document_url: http://d-scholarship-dev.library.pitt.edu/22172/1/licence.txt