TY  - JOUR
ID  - pittir22172
UR  - http://d-scholarship-dev.library.pitt.edu/22172/
IS  - 14
A1  - Werner, S
A1  - Turner, DM
A1  - Lyon, MA
A1  - Huryn, DM
A1  - Wipf, P
Y1  - 2006/09/01/
N2  - A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relationship studies of biological lead molecules. The tandem Biginelli-Ugi multi-component reaction facilitated the effective variation of four different substituents and allowed the synthesis of the library members in a sequence of only two one-pot reactions. © Georg Thieme Verlag Stuttgart.
JF  - Synlett
SN  - 0936-5214
TI  - A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process
SP  - 2334 
AV  - public
EP  -  2338
ER  -