<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma"^^ . "Merkel Cell Carcinoma (MCC) is a rare and highly aggressive neuroendocrine skin cancer for which no effective treatment is available. MCC represents a human cancer with the best experimental evidence for a causal role of a polyoma virus. Large T antigens (LTA) encoded by polyoma viruses are oncoproteins, which are thought to require support of cellular heat shock protein 70 (HSP70) to exert their transforming activity. Here we evaluated the capability of MAL3-101, a synthetic HSP70 inhibitor, to limit proliferation and survival of various MCC cell lines. Remarkably, MAL3-101 treatment resulted in considerable apoptosis in 5 out of 7 MCC cell lines. While this effect was not associated with the viral status of the MCC cells, quantitative mRNA expression analysis of the known HSP70 isoforms revealed a significant correlation between MAL3-101 sensitivity and HSC70 expression, the most prominent isoform in all cell lines. Moreover, MAL3-101 also exhibited in vivo antitumor activity in an MCC xenograft model suggesting that this substance or related compounds are potential therapeutics for the treatment of MCC in the future. © 2014 Adam et al."^^ . "2014-04-02" . . . "9" . "4" . . "PLoS ONE"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . "C"^^ . "Adam"^^ . "C Adam"^^ . . "R"^^ . "Houben"^^ . "R Houben"^^ . . "Michael"^^ . "Sherman"^^ . "Michael Sherman"^^ . . "JC"^^ . "Becker"^^ . "JC Becker"^^ . . "P"^^ . "Wipf"^^ . "P Wipf"^^ . . "JL"^^ . "Brodsky"^^ . "JL Brodsky"^^ . . "A"^^ . "Baeurle"^^ . "A Baeurle"^^ . . "D"^^ . "Schrama"^^ . "D Schrama"^^ . . . . . . "The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma (PDF)"^^ . . . . . . . . "journal.pone.0092041.pdf"^^ . . . "The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . . "The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma (Other)"^^ . . . . . . "preview.jpg"^^ . . . "The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma (Other)"^^ . . . . . . "medium.jpg"^^ . . . "The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma (Other)"^^ . . . . . . "small.jpg"^^ . . . "The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma (Plain Text)"^^ . . . "licence.txt"^^ . . . "The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #21966 \n\nThe HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma\n\n" . "text/html" . .