@article{pittir20680,
          volume = {20},
          number = {3-4},
           month = {March},
          author = {P Wipf and N Jayasuriya},
           title = {Chiral ligand optimization in the asymmetric zirconium-zinc transmetalation aldehyde addition reaction},
         journal = {Chirality},
           pages = {425 -- 430},
            year = {2008},
             url = {http://d-scholarship-dev.library.pitt.edu/20680/},
        abstract = {The in situ hydrozirconation-transmetalation-aldehyde addition process is a convenient method for the generation of allylic alcohols. Ongoing research has focused on enhancing the enantioselectivity and substrate scope of this process. A chiral {\ensuremath{\beta}}-amino thiol scaffold was evaluated in the addition reaction. Amino thiols tend to provide the highest ee's, in part due to the higher affinity of sulfur for zinc over zirconium. A class of valine-based thiol ligands was identified to be effective for the formation of enantiomerically enriched allylic alcohols in terms of low ligand loading and high \% ee. {\copyright} 2007 Wiley-Liss, Inc.}
}