%A P Wipf
%A JL Methot
%J Organic Letters
%T Total synthesis and stereochemical revision of (+)-aeruginosin 298-A
%X (aquation presented) Novel routes toward both enantiomers of the bicyclic proline surrogate 2-carboxy-6-hydroxyoctahydroindole, i.e., Choi, were developed on the basis of the oxidative cyclization of L-tyrosine. Synthesis of the proposed sequence of (+)-aeruginosin 298-A did not provide the natural product. Incorporation of a D-leucine residue, in contrast, led to the total synthesis of this thrombin inhibitor.
%N 26
%P 4213 - 4216
%V 2
%D 2000
%R 10.1021/ol006759x
%L pittir20544