@article{pittir20500, volume = {4}, number = {13}, month = {June}, author = {DP Curran and T Furukawa}, title = {Simultaneous preparation of four truncated analogues of discodermolide by fluorous mixture synthesis}, journal = {Organic Letters}, pages = {2233 -- 2235}, year = {2002}, url = {http://d-scholarship-dev.library.pitt.edu/20500/}, abstract = {(matrix presented) Four analogues made in one synthesis Four truncated analogues of the natural product discodermolide were synthesized in a single synthetic sequence. Precursors bearing four different groups at C22, each with a unique fluorous p-methoxybenzyl substituent on the C17 hydroxy group, were mixed and taken through an nine-step sequence. Demixing by fluorous chromatography followed by deprotection and purification provided the individual analogues in 3-7\% overall yields and with a savings of 24 synthetic steps. Fluorous mixture synthesis is recommended as a new technique to make multiple natural product analogues in a single multistep synthesis.} }