relation: http://d-scholarship-dev.library.pitt.edu/20495/
title: Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases
creator: Wipf, P
creator: Aslan, DC
creator: Southwick, EC
creator: Lazo, JS
description: Based on a previously identified lead structure, SC-ααδ9, we have developed a versatile new chemical scaffold that can be readily modified to generate libraries of both Tyr and dual specificity phosphatase inhibitors with reduced molecular weight and lipophilicity. The most potent analogue identified to date, aminothiazole 8z, inhibits the dual specificity phosphatase Cdc25B with a Ki of 4.6 ± 0.4 μM and a Hill coefficient of 2. © 2001 Elsevier Science Ltd.
date: 2001-02-12
type: Article
type: PeerReviewed
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/20495/1/licence.txt
identifier:   Wipf, P and Aslan, DC and Southwick, EC and Lazo, JS  (2001) Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases.  Bioorganic and Medicinal Chemistry Letters, 11 (3).  313 - 317.  ISSN 0960-894X     
relation: 10.1016/S0960-894X(00)00658-2