@article{pittir20495,
          volume = {11},
          number = {3},
           month = {February},
          author = {P Wipf and DC Aslan and EC Southwick and JS Lazo},
           title = {Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases},
         journal = {Bioorganic and Medicinal Chemistry Letters},
           pages = {313 -- 317},
            year = {2001},
             url = {http://d-scholarship-dev.library.pitt.edu/20495/},
        abstract = {Based on a previously identified lead structure, SC-{\ensuremath{\alpha}}{\ensuremath{\alpha}}{\ensuremath{\delta}}9, we have developed a versatile new chemical scaffold that can be readily modified to generate libraries of both Tyr and dual specificity phosphatase inhibitors with reduced molecular weight and lipophilicity. The most potent analogue identified to date, aminothiazole 8z, inhibits the dual specificity phosphatase Cdc25B with a Ki of 4.6 {$\pm$} 0.4 {\ensuremath{\mu}}M and a Hill coefficient of 2. {\copyright} 2001 Elsevier Science Ltd.}
}